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Creative Biolabs
Product

Mouse Anti-DYSF Monoclonal Antibody (CBP6834)

[CAT#: NAB2007FY1783]

Alzheimer's disease (AD), amyotrophic lateral
sclerosis (ALS), Lewy body dementia (LBD),

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC; WB

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Product Overview

Description

Neuroinflammatory process is a key pathogenic factor Brain and spinal cord injury in the back. This applies not only to Acute brain injury and hypoxic-ischemic brain injury Stroke, but also used for chronic infections and neurodegenerative diseases Diseases such as Alzheimer's disease (AD), amyotrophic lateral cord Sclerosis (ALS), Lewy Body Dementia (LBD) and Multiple Sclerosis (Multiple sclerosis). In addition, local inflammation around the tumor also plays a role In the clinical progression and malignancy of glioblastoma, The most aggressive primary brain tumor. The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2008]

Epitope

Binds to an located within the peptide sequence VDSLVAQLTDELIAG

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP6834

Applications

IHC; WB

Application Notes

IHC: 1:1000-1:2500
WB: 1 µg/ml

Relevant Diseases

Neuroinflammation; Neurodegenerative Disease; Alzheimer's Disease; Amyotrophic Lateral Sclerosis; Lewy body dementia

Research Areas

Neuroinflammation; Neurodegeneration
Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only
Target

Target

DYSF

Official Name

DYSF

Full Name

Dysferlin

Alternative Names

Dysferlin; Limb Girdle Muscular Dystrophy 2B (Autosomal Recessive); Fer-1-Like Family Member 1; Fer-1-Like Protein 1; FER1L1; Dystrophy-Associated Fer-1-Like Protein; Dystrophy-Associated Fer-1-Like 1; LGMD2B; MMD1

Gene ID

8291(Human); 26903(Mouse)

Uniprot ID

O75923(Human); Q9ESD7(Mouse)
Publications

Publications (0)

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For Research Use Only. Not For Clinical Use.
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