Tel:
Fax:
Email:
Creative Biolabs
Product

NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody, Clone 5C1H3

[CAT#: NRZP-1022-ZP4052]

Host Species:
Humanized
Species Reactivity:
Human
Applications:
In Vitro

Datasheet MSDS Request COA

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Inquiry

SPECIFIC INQUIRY

inquiry
Size:
Conjugation:
Endotoxin:
Purity:
Engineering:
Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Clone Number

5C1H3

Applications

In Vitro
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

Alpha Synuclein

Official Name

SNCA

Full Name

Alpha-synuclein

Alternative Names

SNCA; NACP; PARK1; PARK4; PD1; synuclein alpha
Product Pictures

Figure 1 shows the results of passive immunotherapy using 5C1 on the memory performance of the probe portion of the Morris water maze test.

Figure 2 shows the results of passive immunotherapy using 5C1 for speed and error in the round beam test.

ELISA

Figure 3 shows the results of an ELISA assay testing the affinity of different humanized 5C1 antibodies.

WB

Figure 4 shows the results of an alanine scanning mutagenesis experiment used to determine the epitope of α-synuclein bound by the 9E4 antibody.

The upper part of the panel shows the protein of full-length α-synuclein (wild-type or individual point mutations of residues 118-126, as indicated) stained with the 9E4 antibody (left panel) or the control antibody 1H7 (right panel). blot. The lower part of the figure shows the epitope of α-synuclein bound by the 9E4 antibody.

WB

Figure 5 shows the results of an alanine scanning mutagenesis experiment used to determine the epitope of [alpha]-synuclein to which the 5C1 antibody binds.

The upper part of the panel shows full-length α-synuclein (wild-type or a single point mutation in residues 118-126, as indicated) stained with the 5C1 antibody (left panel) or the control antibody 1H7 (right panel). Western blot. The lower part of the figure shows the epitope of α-synuclein bound by the 5C1 antibody.

WB

Figure 6 shows the results of an alanine scanning mutagenesis experiment used to determine the epitope of α-synuclein bound by the 5D12 antibody.

Figure 7 depicts a ball-and-stick model of the amino acids of α-synuclein near the binding site of the 9E4, 5C1 and 5D12 antibodies.

Publications

Publications (0)

gift-card

Related Products
Kits
Neural Genes
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
Send Inquiry Send Inquiry
Inquiry Basket
compare

Send inquiry