NeuroMab™ Anti-NrCAM BBB Shuttle Antibody, Clone N343/26
[CAT#: NRZP-0423-ZP310]
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-NrCAM BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 30-845 (extracellular domain) of mouse NrCAM (also known as Neuronal cell adhesion molecule, Ankyrin-binding cell adhesion molecule, Neuronal surface protein Bravo, NgCAM-related cell adhesion molecule and KIAA0343, accession number Q810U4)
Rat: 96% identity (795/822 amino acids identical)
Human: 91% identity (753/822 amino acids identical)
~50% identity with Neurofascin
Rat: 96% identity (795/822 amino acids identical)
Human: 91% identity (753/822 amino acids identical)
~50% identity with Neurofascin
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Mouse; Rat
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
N343/26
Applications
WB; IHC; ICC
Research Areas
CAMs
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
NrCAM
Official Name
NRCAM
Full Name
NrCAM
Alternative Names
Neuronal Cell Adhesion Molecule; NgCAM-Related Cell Adhesion Molecule; Neuronal Surface Protein Bravo; Ng-CAM-Related; KIAA0343; Nr-CAM; HBravo;
Uniprot ID
Q810U4
Product Pictures
IF
Fig. 1 Immunofluorescence staining of a node of Ranvier in adult rat sciatic nerve with N343/26 (green) and IV-spectrin rabbit polyclonal (red).
Publications
Publications (0)
Kits
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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