NeuroMab™ Anti-OPN BBB Shuttle Antibody,Clone NR1361P
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FC; ELISA; Block; Inhib; In Vitro; In Vivo
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Clonality
Host Species
Clone Number
Applications
Relevant Diseases
Storage
Research Use Only
Target
Official Name
Full Name
Alternative Names
Bone sialoprotein 1;
Bone sialoprotein I;
BSP I;
BSPI;
Early T lymphocyte activation 1;
ETA 1;
ETA1;
MGC110940;
Nephropontin;
OPN;
Osteopontin;
Fig.2 illustrates anti-OPN antibodies, 2G2 and 2H2, blocking binding of purified αvβ3 to the osteopontin antigen, OPN20.
The data are shown as mean±SE for 8 animals, 7 animals and 5 animals in the control group, 25 mg/kg group and 50 mg/kg group, respectively. *p<0.05, **p<0.01: significantly different from control group as determined by Dunnet's multiple comparison test.
Fig.3 illustrates reduction of tumor size of beige nude mice injected with IGROV-1 human ovarian cancer cells using anti-OPN antibodies, 2G2, administered at 13.5 mg/kg or 27 mg/kg.
The data are shown as mean±SE for 8 animals, 7 animals and 5 animals in the control group, 25 mg/kg group and 50 mg/kg group, respectively. *p<0.05, **p<0.01: significantly different from control group as determined by Dunnet's multiple comparison test.
Fig.4 illustrates reduction of tumor size of beige nude mice injected with IGROV-1 human ovarian cancer cells using anti-OPN antibodies, 2G2, in comparison with anti-GP120 antibodies.
The data are shown as mean±SE for 8 animals, 7 animals and 5 animals in the control group, 25 mg/kg group and 50 mg/kg group, respectively. *p<0.05, **p<0.01: significantly different from control group as determined by Dunnet's multiple comparison test.
Fig.5 illustrates reduction of tumor size of beige nude mice injected with IGROV-1 human ovarian cancer cells using anti-OPN antibodies, 2G2, administered at 13.5 mg/kg or 27 mg/kg.
The data are shown as mean±SE for 8 animals, 7 animals and 5 animals in the control group, 25 mg/kg group and 50 mg/kg group, respectively. *p<0.05, **p<0.01: significantly different from control group as determined by Dunnet's multiple comparison test.
Fig.1 illustrates anti-OPN antibodies, 2G2 and 2H2, blocking attachment of MDA-MB-435 highly metastatic human breast carcinoma cells to the osteopontin antigen, OPN20.
The data are shown as mean±SE for 8 animals, 7 animals and 5 animals in the control group, 25 mg/kg group and 50 mg/kg group, respectively. *p<0.05, **p<0.01: significantly different from control group as determined by Dunnet's multiple comparison test.
Publications (0)
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