![](static/images/product/product-icon-neural-antibodies.png)
NeuroMab™ Anti-SORT1 BBB Shuttle Antibody(NRZP-1022-ZP3962)
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- In Vitro; In Vivo; Inhib; ELISA; Block
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 shows the effect of the Sortilin antibody Antibody 45 on the binding of Sortilin PGRN.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3962-1.png)
Figure 2 shows the effect of D-region and D+Sortilin antibodies on the binding of selective small molecule ligand AF38469 to Sortilin.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3962-2.png)
Figure 3 Effects of antibodies 45 and 68 on cellular binding and endocytosis of PGRN.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3962-3.png)
Figure 4 Extracellular PGRN levels estimated by ELISA in media from sortin-overexpressing HEK cell cultures (S18).
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3962-4.png)
Figure 5 shows the effect of Sortilin antibody on extracellular PGRN in neuronally differentiated iPSC cells.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3962-5.png)
Figure 6 Time-course study: Elevated plasma PGRN levels were observed following injection of antibody 45 (Panel D).
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3962-6.png)
Figure 7 Dose-response study: Sortilin (45) and control antibody (Anti-Hel) were injected at different doses (4 doses: 0.1, 0.4, 2 and 10 mg/kg) and mice were sacrificed on day 2.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3962-7.png)
Figure 8 Subchronic study: Mice were treated twice weekly with 10 mg/kg of 45 and a control antibody (anti-Hel).
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3962-8.png)
Figure 9 shows representative peptides covering the 45, 68 and 811 conformational epitopes.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3962-9.png)
Figure 10 shows representative peptides covering the antibody 30 conformational epitope.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3962-10.png)
Figure 11 shows representative peptides covering the antibody 30 conformational epitope.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3962-11.png)
Figure 12 shows the time course: Effect of systemic administration of Antibody 45 or PBS (50 mg/kg, 10 ml/kg, sc) 24 hours before microdialysis experiments on PRGN levels in the hippocampus of freely moving hSORT1 mice over time Over time (24 hours).
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3962-12.png)
Figure 13 shows the results of pooled 24-hour dialysis: Basal PRGN in the hippocampus of freely moving hSORT1 mice was 3.3±0.3 ng/ml and 1.1±0.1 ng/ml in mab#45 and PBS-treated mice, respectively. ml, assessed by push-pull microdialysis.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3962-13.png)
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