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Creative Biolabs
Product

NeuroMab™ Anti-SORT1 BBB Shuttle Antibody,Clone NR2238P

[CAT#: NRZP-1022-ZP3962]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
In Vitro; In Vivo; Inhib; ELISA; Block

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

NR2238P

Applications

In Vitro; In Vivo; Inhib; ELISA; Block

Relevant Diseases

Parkinson's Disease
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

SORT1

Official Name

SORT1

Full Name

Sortilin

Alternative Names

SORT1; Gp95; LDLCQ6; NT3; NTR3; Sortilin 1
Product Pictures
FuncS

Figure 1 shows the effect of the Sortilin antibody Antibody 45 on the binding of Sortilin PGRN.

FuncS

Figure 2 shows the effect of D-region and D+Sortilin antibodies on the binding of selective small molecule ligand AF38469 to Sortilin.

FuncS

Figure 3 Effects of antibodies 45 and 68 on cellular binding and endocytosis of PGRN.

ELISA

Figure 4 Extracellular PGRN levels estimated by ELISA in media from sortin-overexpressing HEK cell cultures (S18).

FuncS

Figure 5 shows the effect of Sortilin antibody on extracellular PGRN in neuronally differentiated iPSC cells.

FuncS

Figure 6 Time-course study: Elevated plasma PGRN levels were observed following injection of antibody 45 (Panel D).

FuncS

Figure 7 Dose-response study: Sortilin (45) and control antibody (Anti-Hel) were injected at different doses (4 doses: 0.1, 0.4, 2 and 10 mg/kg) and mice were sacrificed on day 2.

FuncS

Figure 8 Subchronic study: Mice were treated twice weekly with 10 mg/kg of 45 and a control antibody (anti-Hel).

FuncS

Figure 9 shows representative peptides covering the 45, 68 and 811 conformational epitopes.

FuncS

Figure 10 shows representative peptides covering the antibody 30 conformational epitope.

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Figure 11 shows representative peptides covering the antibody 30 conformational epitope.

FuncS

Figure 12 shows the time course: Effect of systemic administration of Antibody 45 or PBS (50 mg/kg, 10 ml/kg, sc) 24 hours before microdialysis experiments on PRGN levels in the hippocampus of freely moving hSORT1 mice over time Over time (24 hours).

FuncS

Figure 13 shows the results of pooled 24-hour dialysis: Basal PRGN in the hippocampus of freely moving hSORT1 mice was 3.3±0.3 ng/ml and 1.1±0.1 ng/ml in mab#45 and PBS-treated mice, respectively. ml, assessed by push-pull microdialysis.

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For Research Use Only. Not For Clinical Use.
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