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Creative Biolabs

NeuroMab™ Anti-Tau Antibody(NRP-0422-P1014)

[CAT#: NRP-0422-P1014]

Host Species:
Humanized
Species Reactivity:
Human
Applications:
ELISA; In Vitro; In Vivo

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Product Overview

Immunogen

The recombinant human Tau construct, 2N4R isoform (amino acids 2-441), was fused to a N-terminal His-tag to facilitate purification and characterization.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Applications

ELISA; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease
Product Properties

Preservatives

BSA Free

Concentration

1mg/mL

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only
Target

Target

Tau

Official Name

Tau

Full Name

Tau

Alternative Names

CD14

Gene ID

4137(Human); 17762(Mouse); 29477(Rat)

Uniprot ID

P10636(Human); P10637(Mouse); P19332(Rat)
Product Pictures
WB

Figure 1 Western blotting (WB) analysis of general Tau antibody display in brain lysates from Alzheimer's disease (AD) and matched control donors.

ELISA

Figure 2 Tau capture ELISA.

FuncS

Figure 3 shows the pharmacokinetics in mice following a single 10mg/kg intravenous or intraperitoneal injection of anti-Tau antibody.

FuncS

Figure 4 shows that the change over time is flat in macaques following a single IV injection of 50 mg/kg of specific antibodies.

FuncS

Figure 5 shows the concentration of antibodies in the hippocampus of rhesus monkeys at various time points after a single IV injection of 50 mg/kg of the indicated antibodies in rhesus monkeys.

FuncS

Figure 6 shows, on a logarithmic scale, specific antibody injections at different time points after a single IV antibody concentration of 50 mg/kg in the macaque brain.

FuncS

Figure 7 shows the concentration of total Tau in plasma and the concentration of macaque starch antibody in blood after a single IV injection of 50 mg/kg of a specific antibody in macaques.

FuncS

Figure 8 is the plasma antibody concentration after a single intravenous injection of 50 mg/kg specific antibody in rhesus monkeys.

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