Mouse Anti-ANO2 Monoclonal Antibody (CBP6822)

Description

Neuroinflammatory process is a key pathogenic factor Brain and spinal cord injury in the back. This applies not only to Acute brain injury and hypoxic-ischemic brain injury Stroke, but also used for chronic infections and neurodegenerative diseases Diseases such as Alzheimer's disease (AD), amyotrophic lateral cord Sclerosis (ALS), Lewy Body Dementia (LBD) and Multiple Sclerosis (Multiple sclerosis). In addition, local inflammation around the tumor also plays a role In the clinical progression and malignancy of glioblastoma, The most aggressive primary brain tumor. Calcium-activated chloride channels (CaCC) may play a role in olfactory signal transduction. Odor molecules bind to odor-sensing receptors (OSR), leading to increased calcium entry, thereby activating CaCC currents, thereby amplifying the depolarization of OSR cells, and ANO2 appears to be a potential chloride channel involved in this process. May mediate light perception amplification in the retina.

Epitope

Binds to an located within the peptide sequence EPVSLEARLSRMHFH

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP6822

Applications

IHC

Application Notes

IHC: 1:2500-1:5000

Relevant Diseases

Neuroinflammation; Neurodegenerative Disease; Alzheimer's Disease; Amyotrophic Lateral Sclerosis; Lewy body dementia

Research Areas

Neuroinflammation; Neurodegeneration

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

TMEM16B

Official Name

ANO2

Full Name

anoctamin 2

Alternative Names

C12orf3; TMEM16B; chromosome 12 open reading frame 3; transmembrane protein 16B; anoctamin 2; calcium activated chloride channel

Gene ID

57101(Human); 243634(Mouse)

Uniprot ID

Q9NQ90(Human); Q8CFW1(Mouse)