A-Z™ PD Drug Discovery Platform

Creative Biolabs provides you with complete, drug discovery solutions. The combination of our extensive, high-quality, industry-leading drug discovery experience allows us to provide our global clients with the industry's most extensive bespoke service for preclinical drug discovery.

Overview

Parkinson's disease (PD) is the second most common age-associated neurodegenerative disorder. PD is characterized by progressive loss of dopaminergic neurons (DA) located in the substantia niagra parse compacta (SNpc), which play an important role in controlling movement. Loss of neurons that normally release the neurotransmitter dopamine results in motor dysfunction, stiffness, bradykinesia, tremors, postural instability, balance disorders, and sleep disturbances. Animal models have been a mainstay of the drug development pipeline, and mice are frequently used in pharmaceuticals.

In Vitro and In Vivo Models for PD Preclinical Drug Discovery

PD In Vitro Disease Models

• Primary and patient-derived cell models.
• Induced pluripotent stem cell (iPSCs) models.

iPSCs have several advantages as a drug screening platform.

1. They represent normal primary cells with a mostly stable genotype.
2. They possess an intrinsic capacity for self-renewal, facilitating their propagation and expansion for drug screening.

Fig.1 Outline of applications of iPSCs on PD.

• 3D cell culture models

In vitro disease modeling and screening using 3D cell models is particularly useful.

In Vivo Models

• Drosophila models

Drosophila melanogaster is the best in vivo model for studying human diseases. The Drosophila model provides an ideal solution for rapid and cost-effective large-scale screening of phytochemicals as potential drug targets for neurodegenerative diseases, including PD. The Drosophila PD model can be used to screen natural products with anti-inflammatory and antioxidant properties.

• Neurotoxin-Induced Animal Models

The 6-OHDA model is used to examine the neuroprotective function of certain compounds. MPTP is one of the most used neurotoxins in animal models of PD. Animal models of MPTP have been recommended for the study of mitochondrial dysfunction in PD due to their unique antagonistic activity in mitochondria.

• Zebrafish Models

Table. Summary of the advantages of models for PD drug discovery.

Whether you are looking for custom or off-the-shelf solutions, Creative Biolabs provides PD modeling and drug efficacy testing to help accelerate the evaluation of the efficacy of the PD drug candidates you are studying. Please do not hesitate to contact us for in-depth communication with our experts so that we can help you quickly.