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Creative Biolabs

Cells

Cellular models are indispensable in the realm of neuroscience research, offering benefits such as cost-efficiency, easy access, adaptability, and reliable reproducibility. These models serve as in vitro tools for delving into the complexities of cellular dynamics, elucidating the underlying mechanisms, and devising potential therapeutic strategies for neurological disorders.

Creative Biolabs is passionate about offering a broad of reliable and high-quality cell products derived from different species (human, mouse, rat, monkey, rabbit, etc.). We also offer specialized cell culture media and reagents to support your neural cell-based assays in neuroscience research and drug discovery. Our devoted team is steadfast in their commitment to furnish innovative solutions that cater to the requirements of scientists and researchers in the field. Collaborate with Creative Biolabs to access state-of-the-art cell models and resources for your research endeavors.

By Cell Categories By Cell Types By Neurological Disease Models

By Cell Categories

With advanced technologies and stringent standard of quality control, we offer a range of cell products to support your research more cost-effectively. Whether for drug discovery, disease modeling or basic research, our diverse cell repository provides the flexibility and versatility needed to advance scientific knowledge and discovery.

Primary Cells Immortalized Cell Lines iPSC and iPSC-derived Cells
Fig 1: Primary rat olfactory ensheathing Cells. (Creative Biolabs Original)
Maintain the characteristics and functions of the origin of the tissues
Fig 2: An overview of various types of cell immortalization methods. (Chalak, et al., 2024)
Proliferate indefinitely with features close to primary cells
Fig 3: Human ipsc and ipscs-derived neural cells. (Barak, et al., 2022)
Powerful cell models from normal and disease donors
Cell Lines Cell Lysates
Fig 4: Image of cultured GL261 cell line. (Creative Biolabs Original)
More easily transfected compared to primary neural cells and proliferate
Fig 5: Cell lysate is obtained from primary human Schwann cells. (Creative Biolabs Original)
Ready to use, convenient and cost effective

By Cell Types

We are proud to offer dozens of cell types, including but not limited to central and peripheral nerve cells. Each cell type is meticulously characterized and quality-tested to ensure reliability and consistency in research and experimentation.

By Neurological Disease Models

We offer a range of verified cell models specifically used for neurological disease research. Our in vitro models encompass a wide range of neurological conditions to support diverse research needs.

AD related Cells Fig 20: AD is characterised by the inclusion of misfolded amyloid-β (Aβ) and neurofibrillary tangles in pyramidal neurons, primarily in the hippocampus and cortex regions of the brain. (Amartumur, et al., 2024)
PD related Cells Fig 21: PD is characterised by Lewy body aggregates composed of misfolded α-synuclein and degeneration of dopaminergic neurons in the substantia nigra region of the brain. (Amartumur, et al., 2024)
HD related Cells Fig 22: HD is characterized by including mutant Huntingtin protein (mHTT) and degeneration of medium spiny neurons in the basal ganglia, and corpus striatum of the brain. (Amartumur, et al., 2024)
ALS related Cells Fig 23: ALS is characterised by including mutant TAR DNA-binding protein 43 (TDP-43) and other proteins, degeneration of motor neurons in the motor cortex and spinal cord, and muscle atrophy with dysfunctional proteins. (Amartumur, et al., 2024)
Epilepsy related Cells Fig 24: The adenosine hypothesis of SUDEP. (Purnell, et al., 2021)

We also provide custom primary cell isolation services, cell immortalization services, cell line development service and cell-based assay to meet your specific scientific needs by integrating cutting-edge technologies and adhering to strict standards of quality control. Please feel free to contact us to speed up your research progress.

References

  1. Chalak, Mahla, et al. "Cell immortality: in Vitro Effective techniques to achieve and investigate its Applications and challenges." Life 14.3 (2024): 417.
  2. Barak, M et al. "Human iPSC-Derived Neural Models for Studying Alzheimer's Disease: from Neural Stem Cells to Cerebral Organoids." Stem Cell Rev and Rep. 2022, 18(2):792-820.
  3. Bai, Shunjie et al. "1H NMR-based metabolic profiling reveals the effects of fluoxetine on lipid and amino acid metabolism in astrocytes." Int J Mol Sci. 2015, 16(4):8490-8504.
  4. Zabolocki, Michael, et al. "BrainPhys neuronal medium optimized for imaging and optogenetics in vitro." Nature communications 11.1 (2020): 5550.
  5. Kang, Sai, et al. "Characteristic analyses of a neural differentiation model from iPSC-derived neuron according to morphology, physiology, and global gene expression pattern." Scientific reports 7.1 (2017): 12233.
  6. Yamashita, Tomoko, et al. "Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells." PLoS One 12.2 (2017): e0171947.
  7. Tan, Dandan, et al. "Inhibition of RhoA-subfamily GTPases suppresses Schwann cell proliferation through regulating AKT pathway rather than ROCK pathway." Frontiers in cellular neuroscience 12 (2018): 437
  8. Kim, Hyo Min, et al. "Glycation‐mediated tissue‐level remodeling of brain meningeal membrane by aging." Aging Cell 22.5 (2023): e13805.
  9. Sakai, Kiyoshi, et al. "Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms." The Journal of clinical investigation 122.1 (2012): 80-90.
  10. Phelps, Patricia E., et al. "Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair." eLife 13 (2024).
  11. Sun, Xiu, et al. "Direct neuronal reprogramming of olfactory ensheathing cells for CNS repair." Cell death & disease 10.9 (2019): 646.
  12. Amartumur, S et al. "Neuropathogenesis-on-chips for neurodegenerative diseases." Nature Communications. 2024, 15(2219).
  13. Purnell, Benton, et al. "The good, the bad, and the deadly: adenosinergic mechanisms underlying sudden unexpected death in epilepsy." Frontiers in neuroscience 15 (2021): 708304.
  14. Distributed under Open Access license CC BY 4.0 without modification.
  15. Varini, Karine, et al. "Mislocalization of the exitatory amino-acid transporters (EAATs) in human astrocytoma and non-astrocytoma cancer cells: effect of the cell confluence." Journal of biomedical science 19 (2012): 1-12. Distributed under Open Access license CC BY 2.0, without modification.
  16. Bacakova, Lucie, et al. "Vascular smooth muscle cells (VSMCs) in blood vessel tissue engineering: the use of differentiated cells or stem cells as VSMC precursors." Muscle Cell and Tissue-Current Status of Research Field. London, UK: IntechOpen (2018): 289-307. Distributed under Open Access license CC BY 3.0, without modification.
  17. Varini, Karine, et al. "Mislocalization of the exitatory amino-acid transporters (EAATs) in human astrocytoma and non-astrocytoma cancer cells: effect of the cell confluence." Journal of biomedical science 19 (2012): 1-12. Distributed under Open Access license CC BY 2.0, without modification.
For Research Use Only. Not For Clinical Use.

Target

iPSC and iPSC-derived Cells

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