Tandem Pore Domain Potassium Channels

Two-pore domain K⁺ (K2P) channels, or tandem pore-domain potassium ion channels, are a family of 15 members that form the so-called "leak channel." The name of the channel comes from the fact that each subunit has two P (pore) domains in its main sequence. They structurally correspond to the two inward commutator alpha subunits, forming dimers in the membrane. These channels are regulated by a variety of mechanisms, including signal transduction lipids, oxygen tension, pH, mechanical stretching, G protein, volatile anesthetics, acidity / pH, pharmacological agents, heat and signaling events such as phosphorylation and protein-protein interaction. Therefore, the K2P channel represents an important regulator of cell excitability by virtue of its effect on resting potential, and thus has received considerable attention in recent years.

Creative Biolabs provides a variety of products for potassium channel receptors research, including monoclonal antibodies, labeled antibodies, proteins, assay kits, and small molecule activators and inhibitors.

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