Neural Co-Culture Cellular Model Development
Neurons perform a diversity of functions in different parts of the central nervous system (CNS) and are highly specialized for the processing and transmission of cellular signals. Other cell types, also present in the CNS, are glial cells, which have a supportive and protective function for neurons, and they also regulate neuronal function by controlling the microenvironment of neurons and play an important role in neuronal development, growth, migration, and regeneration after damage. Therefore, the establishment of neuronal and glial cell co-culture models is one of the important means to study neurological diseases in vitro and is also the basis for cellular molecular level studies of the nervous system.
Neural Co-Culture Cellular Models
Neural co-culture cellular models provided by Creative Biolabs can better simulate the in vivo environment than single cell cultures, which are closer to the in vivo traits of cells and facilitates the observation of cell-cell and cell-extracellular environment interactions, providing a better platform for in vitro experiments on molecular mechanisms of diseases and new drug development to global neuroscientists.
We can provide multiple cell co-culture modes to meet different experiments for your project.
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It reflects the dynamic interaction and influence between cells. |
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It can reflect the directed response of cells under specific conditions, allowing localization and quantitative analysis. |
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It can simulate in vivo tissues with clear cell distribution levels. |
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The induction of cell migration by chemokines can be observed. |
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There is a dynamic interaction of secretory factors between cells in this culture mode, which can also separate cells accurately and facilitate localization and quantitative study. |
Co-Culture Cellular Models
- Primary neurons-astrocytes co-culture model
- Dopamine neurons-hippocampal astrocytes co-culture model
- Primary neurons-microglia co-culture model
It can be used to study the mechanism of neuronal toxicity in ischemic stroke.
Primary cells are more compatible with in vivo studies to explain cell-cell interactions to develop new drugs for Parkinson's disease (PD).
The mixed culture of primary cells can better reflect the paracrine interaction between neurons and glial cells and can be used to study the mechanism of inflammation-related Alzheimer's disease (AD) in vitro.
At Creative Biolabs, our top research teams can provide you with multiple co-culture cell models in addition to the above.
- Co-culture of neural cell lines and non-neural cells
- Co-culture of primary brain microvascular endothelial cell lines with primary astrocytes
- Co-culture of dopamine neural cell lines
- Co-culture of primary striatal cells with primary fetal brain progenitor cells
- Co-culture of primary brain microvascular endothelial cells with cortical tissue blocks
- Co-culture of primary motor neurons with peripheral nerve cells
Custom Neural Co-Culture Cellular Models Development
For more than a decade, Creative Biolabs has been committed to cutting-edge bioscience, supplying a variety of upstream and downstream biomaterials and customized services to biologists around the world. If you need other co-culture cellular models, please contact us for details and we will customize the most suitable service for your project.
