NeuroMab™ Anti-Tau BBB Shuttle Antibody(NRZP-1022-ZP3149)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse; Humanized

Applications

WB; DB; ELISA; IHC; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Tau

Official Name

MAPT

Full Name

Tau Protein

Alternative Names

MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40

Product Pictures

Figure 1 shows Western blot analysis of HT7, mAb005, and mAb037 on rTg4510 and WT brain lysates.

Figure 2 shows Western blot analysis of HT7, mAb005, and mAb037 on AD and ND brain lysates.

Figure 3 shows Western blot analysis of sarcosyl soluble and insoluble fractions in AD brains by HT7, mAb005, and mAb037.

IHC

Figure 4 shows immunohistochemistry (IHC) of human brain sections with mAb005 (also known as RAA7) and mAb037 for the indicated brain regions and their disease status (ND vs AD), Braak stage (I-VI) and ID markers Dye on top.