NeuroMab™ Mouse Anti-Synapsin I/II/III Monoclonal Antibody (CBP2259)

[CAT#: NAB2010181LS]

Anti-Synapsin I/II/III Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Human; Mouse; Rat

Applications:: WB; IHC-P

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Product Overview

Description

Synapsins are a family of proteins involved in neurotransmitter release at the chemical synapses. Synapsins anchor synaptic vesicles to the cytoskeletal structures at the presynaptic terminal. Upon receiving an action potential, phosphorylation of synapsins, possibly by PKA, leads to the release of synaptic vesicles from cytoskeletal structures. This allows membrane docking and fusion of synaptic vesicles with the presynaptic membrane and neurotransmitter release.

Immunogen

Recombinant protein corresponding to amino acids 362-450 of human Synapsin I

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2259

Applications

WB; IHC-P

Application Notes

WB (0.001-0.005 µg/mL); IHC (0.1-0.5 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1672

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Synapsin

Official Name

Synapsin

Full Name

Synapsin I/II/III

Alternative Names

SYN1; SYN1a; SYN1b; SYNI; Synapsin I; MRX50

Gene ID

6853(Human); 20964(Mouse); 24949(Rat)

Uniprot ID

P17600(Human); O88935(Mouse); P09951(Rat)

References

1. Greengard P, et al. 1993. Science. 259(5096):780
2. Milovanovic D, et al. 2017. Neuron. 93(5):995
3. Evergren E, et al. 2007. J. Neurosci. Res. 85(12):2648

Publications