NeuroMab™ Mouse Anti-Nuclear Pore Complex Proteins Monoclonal Antibody (CBP2340)

[CAT#: NAB2010327LS]

Anti-Nuclear Pore Complex Proteins Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Vertebrate; Xenopus; Yeast

Applications:: ICC; WB; IHC-Fr; IP

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Product Overview

Description

Nuclear pores are large protein complexes that cross the nuclear envelope. The proteins that make up the nuclear pore complex are known as nucleoporins. About half of the nucleoporins typically contain solenoid protein domains-either an alpha solenoid or a beta-propeller fold, or in some cases both as separate structural domains. Each NPC contains at least 456 individual protein molecules and is composed of 30 distinct proteins (nucleoporins). The other half show structural characteristics typical of "natively unfolded" or intrinsically disordered proteins, i.e. they are highly flexible proteins that lack ordered secondary structure. These disordered proteins are the FG nucleoporins, so called because their amino-acid sequence contains many phenylalanine-glycine repeats.

Immunogen

The antibody was raised using a nuclear pore complex mixture.

Species Reactivity

Vertebrate; Xenopus; Yeast

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2340

Applications

ICC; WB; IHC-Fr; IP

Application Notes

ICC (0.5-1 μg/mL); WB (0.2-0.5 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1727

Product Properties

Form

Liquid

Formulation

PBS, containing 0.03% Thimerosal.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Nuclear Pore Complex Proteins

Official Name

Nuclear Pore Complex Proteins

Full Name

Nuclear Pore Complex Proteins

Alternative Names

107 kD nucleoporin; NPC proteins; Nuclear pore complex protein Nup107; Nucleoporin 107kD; Nucleoporin Nup107; NUP 107; NUP 84; NUP107; NUP153; NUP155; NUP84; NUP98

Publications