Mouse Anti-NUMB Monoclonal Antibody (CBP2619)

Product Overview

Description

NUMB plays a role in the determination of cell fates during development. It is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The degradation of NUMB is induced in a proteasome-dependent manner by MDM2. Four transcript variants encoding different isoforms have been found for this gene. The antibody can bind to all these four isoforms P65, P66, P71 and P72, can't recognize the NUMBL.

Expression Host

Mammalian cells

Immunogen

Peptide

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2619

Applications

IF; IHC; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

2000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Numb

Official Name

NUMB

Full Name

Numb homolog

Alternative Names

h Numb; NUMB; numb homolog (Drosophila); Protein numb homolog; Protein S171; S171

Gene ID

8650(Human); 18222(Mouse); 29419(Rat)

Uniprot ID

P49757(Human); Q9QZS3(Mouse); Q2LC84(Rat)

References

1. Wang, N., Wang, D. D., & Shen, Y. (2019). Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors. Neuroscience Letters, 707, 134291. 2. Xu, W., Xu, Y. N., Zhang, X., Xu, Y., Jian, X., Chen, J. M.,... & Mu, Y. P. (2020). Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis. Scientific reports, 10(1), 1-14.

Publications