Anti-NRAS Monoclonal Antibody (CBP3735)

Product Overview

Description

NRAS is a Ras gene family member originally identified in human neuroblastoma cells. Like other members of the Ras family, NRAS has GTP/GDP binding and GTPase activity, and functions as a G-like regulatory protein that plays a role in regulating cell growth. Mutations in NRAS have been shown to transform cultured cells to tumor cells, implicating its role in tumorigeneses, as potential therapeutic target for cancers such as melanoma.

Immunogen

Recombinant human NRAS a.a. 1-186

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP3735

Applications

WB; IHC-P

Application Notes

WB (0.5-2.0 µg/mL); IHC-P (2.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

NRAS

Official Name

NRAS

Full Name

NRAS

Alternative Names

NRAS; ALPS4; CMNS; N-ras; NCMS; NRAS1; NS6; Neuroblastoma RAS viral oncogene homolog; NRAS proto-oncogene; GTPase

Gene ID

4893 (Human); 18176 (Mouse)

Uniprot ID

P01111 (Human); P08556 (Mouse)

References

1. Rocks O, et al. 2005. Science. 307:1746-52.
2. Byrne M, Saif MW. 2019. Onco. Targets Ther. S194605
3. Sexton RE, et al. 2019. Semin. Cancer Biol. 54:131-7.

Publications