Inwardly Rectifying Potassium Channels
Inward rectifier potassium channels (Kir, IRK) are a type of potassium channels that conduct more inward current at the membrane voltage opposite to the K+ equilibrium potential than at positive voltage. This property, defined as inward rectification, enables the channels to operate under negative voltage. To date, seven subfamilies have been identified in various mammalian cell types, plants and bacteria and they are activated by phosphatidylinositol 4,5-bisphosphate (PIP2). Inward rectifier dysfunction is related to many diseases and the channel is the target of many toxins.
Creative Biolabs provides a variety of products for potassium channel receptors research, including monoclonal antibodies, labeled antibodies, proteins, assay kits, and small molecule activators and inhibitors.
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