Cell-Replacement Therapies Study
Cell replacement therapy (CRT) in PD has been a theme of neuroscience for the past few decades, focusing on its use to replace degenerated and lost dopaminergic neuronal cells. Therefore, CRT offers an attractive prospect for the treatment of PD. After years of accumulation, Creative Biolabs has developed into an expert in the field of neuroscience. With our advanced platform and professional scientists, we are confident in providing customized services such as disease modeling and induced stem cell differentiation to accelerate your PD mechanism of action (MoA) studies.
Overview of CRT
CRT is a significant approach for exploring and treating various diseases, especially PD. The basic principle of CRT is to restore the function of the central nervous system lost due to injury or disease by replacing dead cells with new healthy cells. CRT is a hopeful strategy to achieve long-term improvement in exercise by preventing disease progression. In short, CRT was beneficial to increase dopaminergic neurons, which was confirmed by positron emission tomography and immunostaining. In PD, the engraftment of specific cells may be able to replace those dopamine neurons that are lost during the disease process.
CRT for PD
It is well known that many of the key motor symptoms and signs of PD result from the loss of midbrain dopamine (DA) neurons. This fact means that replacing just one cell type in a localized brain region may help alleviate some of the notable defects. Therefore, PD has long been regarded as the pioneer of CRT. Current research focuses on the pluripotent potential of various forms of stem cells. By inducing stem cells to differentiate under suitable conditions, dopaminergic neurons can be generated. These neurons could be transplanted into patients with PD, replacing their dopamine levels and helping with symptom relief. Stem cells, for their capacity to expand indefinitely and give rise to large numbers of specialized cells, are nowadays thought to be the main cell source candidates for CRT.
Fig.1 iPSC toolbox for PD disease modeling. (Simmnacher, et al., 2020)
Stem Cells in CRT
Several promising sources of stem cells have received considerable attention in providing functional dopaminergic replacement neurons, such as neural stem cells (NSCs), embryonic stem cells (ESCs), mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs). Notably, ESCs and iPSCs constitute a renewable source of human cells capable of differentiating in any cell type in the mature human body. The advantages of ESCs and iPSCs lie in the availability of an almost unlimited number, the standardization of manufacturing procedures and the possibility of cryopreservation.
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Reference
- Simmnacher, K.; et al. Modeling cell-cell interactions in Parkinson's disease using human stem cell-based models. Frontiers in Cellular Neuroscience. 2020, 13: 571.
