Epilepsy and Seizures
Introduction
Epilepsy is a common neurologic condition in which neurons and neuronal networks malfunction to cause the sometimes dramatic symptoms of seizures. Epilepsy usually results in unpredictable, unprovoked recurrent seizures that affect a variety of mental and physical functions. Epileptic seizures are manifested by an abnormal, excessive, and hypersynchronous electrical discharge of neurons in the brain.
Approximately 75% of epilepsy begins in childhood, reflecting the heightened susceptibility of the developing brain to seizures. Also, epilepsy is one of the nervous system diseases in the elderly, second to dementia and stroke. Geriatric epilepsy includes pre-elderly epilepsy continuing to the old age stage and new-onset epilepsy in the elderly. People without epilepsy can experience symptomatic seizures-the structure and function of the brain carries the risk of generating seizures if exposed to convulsant drugs or conditions.
- Symptoms
- Etiologies
A seizure is a transient epileptic event, indicating a disturbance in brain function and last from a few seconds to a few minutes. It includes a series of signs or symptoms, such as convulsions, brief loss of consciousness, blank staring, isolated posturing, or jerking of a single limb. Other possible conditions include sleep disorders, panic attacks, migraines, cataplexy, recurrent transient global amnesia, and psychogenic pseudoseizures.
Epilepsy and seizure have numerous causes, each reflecting underlying brain dysfunction. Head trauma and genetic cause are common causes of epilepsy. New-onset epilepsy in the elderly mainly results from accumulated brain injuries and other secondary factors. The most common acquired etiologies include cerebrovascular diseases, degenerative disorders associated with cognitive impairment, CNS tumors, and traumatic head injury. In addition, metabolic disturbances such as electrolyte imbalances, hypoglycemia or hyperglycemia, endocrine disorders, hematological disorders, renal failure, and hepatic failure may cause seizures at any age.
Genetic Factors
There has been an explosion of information about the genetic basis of epilepsy syndromes. The most common form of generalized-onset epilepsy appears to be a polygenic disease. Expression of the phenotype requires the simultaneous inheritance of multiple genes. A specific disease-causing variant in a gene or copy number variant is believed to be pathogenic for epilepsy. Both monogenic and polygenic mutations lead to epilepsy. Genetic pathologies leading to epilepsy can occur anywhere from the circuit level (e.g., abnormal synaptic connectivity) to the receptor level (e.g., abnormal γ-aminobutyric acid [GABA] receptor subunits) to abnormal ionic channel function (e.g., potassium channel mutations). As knowledge of genetic factors expands, there is hope that syndrome-specific therapeutic interventions can be designed.
Immune Factors
Autoimmune disease is one of the causes of new-onset epilepsy. Epilepsy and autoimmune encephalitis have been linked to neuronal intracellular antibodies (GAD65, ANNA-1, and Ma) and neuronal cell surface antibodies (VGKC complex, NMDAR, AMPA, GABA-B, and GluR5).
Diagnosis and Treatment
Many seizures, characteristic behavioral changes, and electrophysiological disturbances can usually be detected in scalp electroencephalographic (EEG) recordings. Others such as normal MRI and neurologic examination can also be used for recognizing the seizure. Since the genetic basis of epilepsies becomes progressively unraveled, clinical testing will occupy an increasingly pivotal role in the clinic.
Once epilepsy is established, AEDs are the first line of treatment. Each distinct form of epilepsy has its natural history and response to treatment. After a first seizure, the risks of future seizure recurrence must be weighed against the risks and benefits of starting antiepileptic drugs (AEDs). If medication fails to control seizures, there are other options for epilepsy control, including resective epilepsy surgery (lesionectomy, hemispherotomy) and palliative epilepsy surgery (stimulation therapy, callosotomy).
Products Provided by Creative Biolabs
With our extensive experience and advanced platform, Creative Biolabs is confident in offering our global customers the best-quality services and products. Our experts offer different types of specific products for your research, including but not limited to animal models, vectors, cell lines, proteins & peptides, and antibodies.
GABA | GAD65 | NMDAR |
AMPA | GluR5 |
Please directly contact us to see more detailed information. We look forward to discussing your inquiry and finding the best solution for your needs.
- iNeuMab™ Anti-Tau Antibody (NRP-0422-P2275) (Cat#: NRP-0422-P2275)
- iNeuMab™ Anti-FGFR1 Antibody (NRP-0422-P1244) (Cat#: NRP-0422-P1244)
- iNeuMab™ Anti-TREM2 Antibody (NRP-0422-P792) (Cat#: NRP-0422-P792)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- iNeuMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- iNeuMab™ Anti-Amyloid Beta 1-15 Antibody (NRP-0422-P867) (Cat#: NRP-0422-P867)
- iNeuMab™ Anti-Tau Antibody (NRP-0422-P2293) (Cat#: NRP-0422-P2293)
- iNeuMab™ Anti-TREM2 BBB Shuttle Antibody (NRZP-1022-ZP4114) (Cat#: NRZP-1022-ZP4114)
- iNeuMab™ Anti-Alpha Synuclein BBB Shuttle Antibody (NRZP-1022-ZP4050) (Cat#: NRZP-1022-ZP4050)
- Mouse Glioma Cell Line GL-261-Luc (Cat#: NCL-2108P06)
- Green Fluorescent BACE1 Cell Lines (Cat#: NCL2110P214)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- Mouse Glioma Cell Line GL261-GFP (Cat#: NCL-2108P04)
- Green Fluorescent Alpha-synuclein Cell Line (Cat#: NCL2110P209)
- Human Dental Pulp Stem Cells (Cat#: NRZP-1122-ZP113)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- iNeu™ Human Schwann Cell (Cat#: NCL-2103-P63)
- iNeu™ Human Motor Neurons (Cat#: NCL-2103-P71)
- Mouse Microglia N9 (Cat#: NCL2110P073)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)