In Vitro, In Vivo & Ex Vivo Electrophysiology Assay

Neuroelectrophysiology is a method of recording or measuring electrical properties, membrane potential conduction velocity, and ion channel activity in whole animals or isolated organ tissues, nerves, and, cellular ion channels using electrophysiological instruments, microelectrodes, voltage clamp, and patch clamp techniques. Electrical properties of neural tissue are important in various applications such as therapeutic electrical stimulation of the nervous system, electrical impedance tomography (EIT), and interpretation of intrinsic electrical signals in neuroscience.

At Creative Biolabs, we provide in vitro, in vivo, and ex vivo neuron electrophysiological assay services for our global clients, facilitating your study of neuropathophysiology, pharmacology, and signal transduction processes at the cellular and molecular levels.

Neuroelectrophysiology Models at Creative Biolabs

• Rat hippocampal tissue slice models

The rat hippocampal tissue slice model is an acute brain slice model that has been used as a model for in vitro electrophysiological assays because it preserves the in vivo-like stereotype and temporal organization and structural integrity of neuronal microcircuits.

• Brain Slice and Dissociated Neuron Model

Our scientists use cerebellar brain slices and isolated primary cerebellar neuronal cultures obtained from adult rats and nonhuman primate adult animals for pharmacological assessment of neuronal safety in the central nervous system.

Ion Channel Targets

We can perform in vitro electrophysiology and ex vivo assays on the following ion channel targets.

• Voltage-gated Ion Channels

(K+) hERG

(Na+) Nav 1.5, Nav 1.7, Nav 1.1

• Ligand-gated Ion Channels

TRP Family (TRPV1, V3, C6)

P2X Family (P2X3, 4, 7)

GABAaR (1α, 2β, γ2)

GluR (AMPA, NMDA) Family

Electrophysiology Assay Services

• Mature experimental process

• A complete experimental system

Creative Biolabs has mature biological research technology and experienced technicians. In the past 20 years, we have provided a variety of satisfactory services to scientific researchers worldwide. Here, we would like to emphasize our high professionalism in neuron electrophysiology experiments. We have a leading experimental platform and the most advanced technology. We are also willing to answer your questions and provide high-quality customized services in neuron electrophysiology. Please contact us for more technical support.