Product Overview

Description

The antibody has a pH-dependent antigen-binding antigen, and therefore have greater affinity for antigen binding at physiological pH than at endosomal pH. This can increase the antibody half-life compared to an antibody with an equivalent KD at pH 7.4 but no pH-dependent binding. Antibodies with pH-dependent binding can also prolong the reduction of antigens that are not bound to the antibody. This may be important when antagonizing target antigens that are usually present at high levels.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

Antagonist; In Vitro

Relevant Diseases

Alzheimer's Disease; Stroke; Neuroinflammation

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

PSK9

Official Name

PCSK9

Full Name

Proprotein Convertase Subtilisin/Kexin Type 9

Alternative Names

Proprotein Convertase Subtilisin/Kexin Type 9; Subtilisin/Kexin-Like Protease PC9; NARC-1; NARC1; PC9; Convertase Subtilisin/Kexin Type 9 Preproprotein; Hypercholesterolemia; Autosomal Dominant 3; Neural Apoptosis Regulated Convertase 1; Neural Apoptosis-Regulated Convertase 1;