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Creative Biolabs
Product

NeuroMab™ Anti-CD3 BBB Shuttle Antibody, Clone NR284P

[CAT#: NRZP-1022-ZP3911]

Host Species:
Human
Species Reactivity:
Human
Applications:
FC; In Vitro; In Vivo

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Clone Number

NR284P

Applications

FC; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

CD3

Official Name

CD3

Full Name

CD3e molecule, epsilon (CD3-TCR complex)

Alternative Names

CD3; CD3e molecule; epsilon (CD3-TCR complex)
Product Pictures
FCM

Figure 1 Binding of antibodies containing MF5196 VH; MF5603 VH; MF5616 VH; MF5626 VH; MF5630 VH; chain.

FCM

Figure 2 Binding of the PG form to membrane-expressed CD3 on HPB-ALL cells All of these examples bound to CD3.

FCM

Figure 3 Binding of the PG form to membrane-expressed CD3 on HPB-ALL cells All of these examples bound to CD3.

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For Research Use Only. Not For Clinical Use.
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