Mouse Anti-CD3 Monoclonal Antibody (CBP2631)

Product Overview

Description

CD3 is a complex of proteins that directly associates with the T cell receptor (TCR). The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. The TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. TCR-mediated peptide-MHC recognition is transmitted to the CD3 complex, leading to the intracellular signal transduction. CD3 is considered to be a pan-T cell marker for detection of normal and neoplastic T cells.

Expression Host

Mammalian cells

Immunogen

CD3 fusion protein Ag11797

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP2631

Applications

FC; IF; IHC; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

700 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD3

Official Name

CD3

Full Name

CD3e molecule, epsilon (CD3-TCR complex)

Alternative Names

CD3; CD3 epsilon; CD3E; CD3-epsilon; T3E; TCRE

Gene ID

919(Human); 12500(Mouse); 25300(Rat)

Uniprot ID

P20963(Human); P04235(Mouse); P19377(Rat)

References

1. Zhang, Y., Xu, J., Hua, J., Liu, J., Liang, C., Meng, Q.,... & Shi, S. (2019). A PD-L2-based immune marker signature helps to predict survival in resected pancreatic ductal adenocarcinoma. Journal for immunotherapy of cancer, 7(1), 1-13. 2. Zhang, C., Gao, J., He, J., Liu, C., Lv, X., Yin, X.,... & Tian, Z. (2020). Regulatory T-cell expansion in oral and maxillofacial Langerhans cell histiocytosis. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 3. Ma, R., Jiang, W., Li, Z., Sun, Y., & Wei, Z. (2016). Intrarenal macrophage infiltration induced by T cells is associated with podocyte injury in lupus nephritis patients. Lupus, 25(14), 1577-1586.

Publications