NeuroMab™ Anti-IL-6 Antibody,Clone NR2543P

Product Overview

Description

CLB8 monoclonal antibody specifically binds to human IL-6. It was shown that injection of CLB8 prolonged the survival of human tumor bearing mice. It was also reported that mCLB8 anti-IL-6 antibody regressed growth of human renal carcinoma tumors and decreased serum calcium concentrations in nude mice.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Clone Number

NR2543P

Applications

WB; Inhib; Neut; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

IL-6

Official Name

IL6

Full Name

Interleukin 6 (IL-6)

Alternative Names

IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6

Gene ID

3569(Human)

Uniprot ID

P05231(Human)

Product Pictures

ELISA

Figure 1 shows a graph showing the binding of cCLB8 to human recombinant IL-6.

Inhib

Figure 2 graph showing the inhibition of IL-6-mediated IgM mu secretion from SKW6.4 cells by cCLB8.

Inhib

Figure 3 is a graph showing the inhibition of IL-6-mediated MCP-1 production by cCLB8.

Figure 4. Western blot images showing cCLB8 inhibits IL-6 signaling in THP-1 human monocytic leukemia cells.

Inhib

Figure 5 is a graph showing that cCLB8 inhibits IL-6-induced serum amyloid A production in HepG2 cells.

Neut

Figure 6 is a graph showing the ability of cCLB8 to neutralize rhIL-6-induced cell proliferation.

FuncS

Figure 7 is a graph showing the relative reduction in body weight loss in tumor-bearing mouse hosts treated with anti-human and anti-mouse IL-6 antibodies.

Publications