Mouse Anti-Glycine Transporter 2 Monoclonal Antibody (CBP2271)

Product Overview

Description

Glycine transporter 2 (GlyT2) protein is encoded by the SLC6A5 gene. It is one of the major glycine transporters that is expressed predominantly in the brain stem and spinal cord, and is frequently used as cellular marker for glycinergic neurons in the central nervous system. Mutations in the SLC6A5 gene have been clinically linked to hyperekplexia 3, which has been thought to be caused by disruption of inhibitory neuronal transmission.

Immunogen

Synthetic peptide corresponding to a.a. 182-199 of mouse SLC6A5

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP2271

Applications

WB; ICC

Application Notes

WB (1- 5 µg/mL); ICC (2-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Glycine Transporter 2

Official Name

SLC6A5

Full Name

Sodium- and chloride-dependent glycine transporter 2

Alternative Names

SLC6A5; GLYT-2; GLYT2; HKPX3; NET1; Glycine transporter 2; solute carrier family 6 member 5

Gene ID

9152(Human); 104245(Mouse); 171148(Rat)

Uniprot ID

Q9Y345(Human); Q761V0(Mouse); P58295(Rat)

References

1. Zafra F, et al. 2017. Adv Neurobiol. 16:55.
2. Lopez-Corcuera B, et al. 2017. Adv Neurobiol. 16:13.
3. Vandenberg RJ, et al. 2014. Trends Pharmacol Sci. 35(8):423.

Publications