Mouse Anti-CD80 Monoclonal Antibody (CBP3016)

Product Overview

Description

CD80 is a type I membrane protein that is a member of the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, monocytes, and macrophages. CD80 is the receptor for the proteins CD28 and CTLA-4 found on the surface of T-cells. It is involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. CD80 also acts as a cellular attachment receptor for adenovirus subgroup B.

Expression Host

Mammalian cells

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP3016

Applications

Research Areas

Growth and Development

Conjugation

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

5 µl(0.5µg)/test

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD80

Official Name

CD80

Full Name

CD80 molecule

Alternative Names

Activation B7 1 antigen; B7; B7 1; B7-1; BB1; CD28LG; CD28LG1; CD80; CD80 molecule; CTLA 4 counter receptor B7.1

Gene ID

941(Human)

Uniprot ID

P33681(Human)

References

1. Juan, C., Wang, Q., Mao, Y., Cao, Q., Qiao, C., Zhang, D., & Zhou, G. (2018). Knockdown of LncRNA MALAT1 contributes to cell apoptosis via regulating NF-κB/CD80 axis in neonatal respiratory distress syndrome. The international journal of biochemistry & cell biology, 104, 138-148. 2. Juan, C., Wang, Q., Mao, Y., Cao, Q., Qiao, C., Zhang, D., & Zhou, G. (2018). Knockdown of LncRNA MALAT1 contributes to cell apoptosis via regulating NF-κB/CD80 axis in neonatal respiratory distress syndrome. The international journal of biochemistry & cell biology, 104, 138-148. 3. Li, Y., Bai, W., & Zhang, L. (2020). The overexpression of CD80 and ISG15 are associated with the progression and metastasis of breast cancer by a meta-analysis integrating three microarray datasets. Pathology & Oncology Research, 26(1), 443-452.

Publications