Tel:
Fax:
Email:
Creative Biolabs
Product

iNeu™ Glutamatergic Neurons MAPT P301S/WT, ALS Model

[CAT#: NRZP-0323-ZP10]

Human iPSC-derived ALS and FTD disease model

Species:
Human
Cell Types:
Glutamatergic Neuron

Datasheet MSDS Request COA

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Inquiry
Product Overview

Description

The iNeu™ Glutamatergic Neuron MAPT P301S/WT, ALS Model is a rapidly maturing, consistent and scalable isogenic system for the study of frontotemporal dementia (FTD). They are precisely reprogrammed glutamatergic neurons carrying genetically engineered heterozygous P301S mutations in the MAPT gene encoding tau protein. These cells are part of a range that includes both homozygous MAPT P301S mutations and heterozygous MAPT N279K mutations. When paired with genetically matched control wild-type iNeu™ glutamatergic neurons, these disease model cells provide a physiologically relevant model to study the effects of mutant tau protein on disease progression.

Features

Making real comparisons
Disease model cells were paired with genetically matched wild-type glutamatergic neurons to study the effects of mutant TDP-43 proteins on disease progression.

Scalable
Available in industrial-scale quantities, with industry-leading seeding densities, and at an affordable price, cells can be used from research to high-throughput screening.

Fast
Disease model cells and isogenic controls were ready for experiments as early as 2 days after resuscitation and formed structural neuronal networks by 11 days.

Cell Types

Glutamatergic Neuron

Application Notes

FTD and ALS research
Drug discovery and development
Disease modelling
High-throughput screening
Electrophysiological assays (MEA)
Co-culture studies

Mutation Description

Heterozygous P301S missense mutation in the MAPT gene

Relevant Diseases

FTD; ALS

Species

Human
Properties

Size

>1 x 10^6 viable cells

Form

Frozen

Cell State

Cryopreserved cells

Growth Pattern

Adherent

Seeding Density

6, 12, 24, 48, 96 & 384 well plates

Tissue Source

Skin fibroblast

Shipping

Dry ice

Storage

LN2 or -150°C

Quality Control

Sterility, protein expression (ICC), gene expression (RT-qPCR) and genotype validation
Donor Information

Gender

Male

Donor Age

Adult

Ethnicity

Caucasian

Additional Donor Information

Normal (46, XY)
Publications

Publications (0)

gift-card

Related Products
For Research Use Only. Not For Clinical Use.
Send Inquiry Send Inquiry
Inquiry Basket
compare

Send inquiry