iNeu™ Glutamatergic Neurons HTT 50CAG/WT, HTT Model
[CAT#: NRZP-0323-ZP7]
A rapidly maturing, consistent and scalable isogenic system to study Huntington's disease.
- Species:
- Human
- Cell Types:
- Glutamatergic Neurons
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Overview
Description
Human iPSC-derived Huntington's Disease Model: Glutamatergic Neurons HTT 50CAG/WT are precisely reprogrammed glutamatergic neurons containing a genetically engineered heterozygous 50 CAG in exon 1 of the huntingtin (HTT) gene Trinucleotide repeat expansion. Disease model cells display Huntington's disease-associated phenotypes, manifested by delayed neuronal network formation and reduced spontaneous activity compared with isogenic control, wild-type glutamatergic neurons.
Features
Disease-associated phenotypes
Microelectrode array analysis revealed delayed neuronal network formation and reduced spontaneous activity compared with wild-type controls.
Scalable
Industrial-scale quantities have industry-leading seeding densities, and the price point allows cells to be used from research to high-throughput screening.
Microelectrode array analysis revealed delayed neuronal network formation and reduced spontaneous activity compared with wild-type controls.
Scalable
Industrial-scale quantities have industry-leading seeding densities, and the price point allows cells to be used from research to high-throughput screening.
Neurological Disease Models
HD-related Cells
Cell Types
Glutamatergic Neurons
Application Notes
Huntington's disease research
Drug discovery
Disease modelling
Electrophysiological assays (MEA)
Co-culture studies
Drug discovery
Disease modelling
Electrophysiological assays (MEA)
Co-culture studies
Mutation Description
Heterozygous - HTT 50 CAG repeat expansion
Relevant Diseases
Huntington's Disease
Species
Human
Properties
Size
>1 x 10^6 viable cells
Form
Frozen
Cell State
Cryopreserved cells
Growth Pattern
Adherent
Seeding Density
6, 12, 24, 48, 96 & 384 well plates
Tissue Source
Skin fibroblast
Shipping
Dry ice
Storage
LN2 or -150°C
Quality Control
Sterility, protein expression (ICC), gene expression (RT-qPCR) and genotype validation
Donor Information
Gender
Male
Donor Age
Adult
Ethnicity
Caucasian
Additional Donor Information
Normal (46, XY)
Publications
Publications (0)
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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