Huntingtin Antibodies

Huntington's disease (also known as Huntington's chorea, HD) is a neurodegenerative disorder characterized by the loss of striatal neurons, with clinical manifestations including involuntary dancing movements, cognitive impairment, and mental retardation. Because the biochemical activity of the disease-causing mutant huntingtin protein (mHTT) is unknown and cannot be targeted, the traditional method of relying on inhibitors to block the activity of the pathogenic protein is not applicable.

Huntingtin (Htt) is a protein encoded by the HTT gene. Htt mutations can cause changes in the conformation of the protein, leading to abnormal aggregation in cells, resulting in neuronal death and progressive neurodegeneration.

HD and Htt

There is an abnormal increase in CAG trinucleotide repeats in the HTT gene in HD patients, which manifests as polyglutamine expansion at the protein level. The pathological manifestations are the death of basal ganglia striatal neurons and brain atrophy. The clinical symptoms of HD are chorea, cognitive impairment, and psychiatric disorders.

The incidence of HD is closely related to the number of polyglutamines (polyQ) in Htt. In normal individuals, Htt typically contains 11 to 34 glutamine residues. When the number of polyQ in Htt is greater than 35, HD is caused. The more polyQ there is, the earlier the disease occurs and the more severe it is. Htt contains 3144 amino acids and is widely expressed in various tissues of humans and rodents, with the highest expression in central neurons and testes. Htt has important biological functions and plays a key role in various stages of development. It can resist apoptosis, promote vesicle trafficking, participate in clathrin-regulated cell endocytosis, regulate dendritic morphology, and participate in transcriptional regulation.

Htt Antibodies Selection Guide

Creative Biolabs offers a library of Htt antibodies that can be used for a wide range of applications. These antibodies bind to human, rat, and mouse Htt. If you don't see the antibody you need, get in touch with us and we can custom-make antibodies for particular targets, species, and uses.

See all Htt antibodies