Product
NeuroMab™ Mouse Anti-Huntingtin Monoclonal Antibody (CBP1945)
[CAT#: NAB2007FY405]
Mouse Monoclonal [HDB4E10] to Huntingtin
- Host Species:
- Mouse
- Species Reactivity:
- Human; Rat; Mouse
- Applications:
- IHC-Fr; WB; IP
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The mouse anti-Huntingtin antibody clone HDB4E10 reacts with an epitope corresponding to the HDB region (amino acids 1844-2131) of the Huntingtin protein.
The mouse anti-Huntingtin antibody, clone HDB4E10, can detect a band of about 350 kDa on Western blot, but it can also detect smaller degradation products of huntingtin. The combined use of mouse anti-Huntingtin antibody, clone HDB4E10 (MCA2050) and HDC8A4 (MCA2051) proved that huntingtin is enriched in neuronal cells of the brain (Jones 1999).
The mouse anti-Huntingtin antibody, clone HDB4E10, can detect a band of about 350 kDa on Western blot, but it can also detect smaller degradation products of huntingtin. The combined use of mouse anti-Huntingtin antibody, clone HDB4E10 (MCA2050) and HDC8A4 (MCA2051) proved that huntingtin is enriched in neuronal cells of the brain (Jones 1999).
Immunogen
Recombinant protein, corresponding to amino acids 1842-4131 of Huntingtin protein.
Species Reactivity
Human; Rat; Mouse
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1
Clone Number
CBP1945
Applications
IHC-Fr; WB; IP
Relevant Diseases
Huntington's Disease
Research Areas
Neuroregeneration
Conjugation
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1577
Product Properties
Form
Liquid
Formulation
PBS; 0.09% Sodium Azide
Preservatives
Yes
Concentration
1.0 mg/ml
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store at +4°C or at -20°C if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Shirasaki, D.I. et al. (2012) Network organization of the huntingtin proteomic interactome in mammalian brain.
2. Jones, A.L. (1999) The localization and interactions of huntingtin.
3. Tao, T. & Tartakoff, A.M. (2001) Nuclear relocation of normal huntingtin.
4. Massai, L. et al. (2013) Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.
2. Jones, A.L. (1999) The localization and interactions of huntingtin.
3. Tao, T. & Tartakoff, A.M. (2001) Nuclear relocation of normal huntingtin.
4. Massai, L. et al. (2013) Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.
Publications
Publications (0)
Neural Cell Lines
Neural Antibodies
Neural Genes
Kits
For Research Use Only. Not For Clinical Use.
