Schwann Cell Markers
Schwann cells are nerve fibers that produce myelin in the peripheral nervous system (PNS). Their function is equivalent to oligodendrocytes in the central nervous system (CNS). They form a myelin sheath around the axon and have multiple functions such as providing structural support, conducting nerve impulses along the axon, removing debris after axon injury, and guiding axon regenerations.
Schwann cells further differentiate into Schwann cell precursors and immature Schwann cells during embryo development. After the premyelination Schwann cell stage, mature myelinated and unmyelinated Schwann cells are formed. Upon peripheral nerve injury, mature Schwann cells at the distal stump will differentiate into immature Schwann cells, and then differentiate into mature myelinated and unmyelinated Schwann cells after nerve regeneration.
Fig.1 Differentiation stages of Schwann cells and commonly expressed markers.
Creative Biolabs provides a series of research tools needed to study the function of Schwann cells. Our product portfolio includes monoclonal antibodies, polyclonal antibodies, labeled antibodies, proteins, analytical kits, and small molecule activators and inhibitors.
With our easy-to-use guide below, make sure you choose the best cell marker tools for your research needs.
Summary of Schwann Cell Markers Provided by Creative Biolabs
|Schwann cell precursor||SOX10, GAP43, BLBP, MPZ, Dhh, P75NTR, OCT6, SOX2|
|Immature Schwann cell||SOX10, GAP43, S100, P75NTR, NCAM, MPZ, SOX2, OCT6|
|Pro-myelin Schwann cell||SOX10, S100, KROX20, OCT6|
|Myelinating Schwann cell||SOX10, S100, KROX20, Myelin Basic Protein, MPZ, EGR2|
|Non-myelinating Schwann cell||SOX10, S100, GAP43, NCAM, P75NTR|