iNeuMab™ Anti-Lgi1 BBB Shuttle Antibody (NRZP-0423-ZP242)
[CAT#: NRZP-0423-ZP242]
- Species Reactivity:
- Rat; Mouse; Human
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-LGI1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse Lgi1 (also known as Leucine-rich glioma-inactivated protein 1, Epitempin-1, EPT and UNQ775/PRO1569, accession number Q9JIA1)
Rat: 100% identity (77/77 amino acids identical)
Human: 98% identity (76/77 amino acids identical)
~50% identity with Lgi2, Lgi3 and Lgi4
Rat: 100% identity (77/77 amino acids identical)
Human: 98% identity (76/77 amino acids identical)
~50% identity with Lgi2, Lgi3 and Lgi4
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse; Human
Clonality
Monoclonal
Isotype
IgG2a
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
LGI1
Official Name
LGI1
Full Name
Lgi1
Alternative Names
LGI1; ADLTE; ADPAEF; ADPEAF; EPITEMPIN; EPT; ETL1; IB1099; leucine-rich; glioma inactivated 1; leucine rich glioma inactivated 1
Uniprot ID
Q9JIA1
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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