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Creative Biolabs

Intermediate Neurofilament Antibody Panel (NF-L, NF-M,NF-H)

[CAT#: NRZP-0323-ZP132]

Antibody Panel for Intermediate Neurofilament (NF-L, NF-M,NF-H)

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Product Overview

Description

Neurofilaments are structural components of neurons that consist of three subunits: NFL, NFM, and NFH. These subunits assemble into heterotetrameric units, which form protofilaments, and eight protofilaments make up the final 10 nm intermediate filament. NFL plays a critical role in the assembly of neurofilaments and the maintenance of axonal caliber, while NFM helps stabilize the filament network and aids in longitudinal extension. NFH also forms cross-bridges and may interact with other cytoskeletal elements. Neurofilament accumulations are found in several neurological diseases, including ALS, Parkinson's disease, some dementias, Alzheimer's disease, and other neuropathies.
Product Properties

Components

anti-Neurofilament NF-L antibody
anti-Neurofilament NF-M antibody
anti-Neurofilament NF-H antibody
Goat anti-Mouse IgG antibody (HRP)
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For Research Use Only. Not For Clinical Use.
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