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![](static/images/product/product-icon-neural-antibodies.png)
NeuroMab™ Anti-TREM2 Antibody, Clone NR66P
A functional antibody raised against Human, Cynomolgus Monkey TREM2.
- Host Species:
- Humanized
- Species Reactivity:
- Human; Cynomolgus Monkey
- Applications:
- FC; ELISA; In Vitro; Agonist; In Vivo
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryDescription
Species Reactivity
Clonality
Host Species
Clone Number
Applications
Relevant Diseases
Formulation
Preservatives
Concentration
Purification
Purity
Endotoxin Level
Low Endotoxin < 1 EU/mg
Shipping
Storage
Research Use Only
Figure 1 shows the increased agonistic activity of Fc variant anti-TREM2 antibodies. Luciferase activity of Fc variant antibodies co-cultured with BWZ reporter cells and THP-1 cells at a ratio of 1:1 for 6 hours.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P711-1.png)
Figure 2 shows the increased agonistic activity of Fc variant anti-TREM2 antibodies. Luciferase activity after 6 hours incubation with Fc variant of anti-TREM2 antibody.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P711-2.png)
Figure 3 shows C3b deposition induced by Fc variant anti-TREM2 antibodies. Fold change in C3b deposition on HEK expressing TREM2 cell lines of AL2p Fc variants relative to human IgG1 isotype control antibody at 10 μg/mL.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P711-3.png)
Figure 4 shows C3b deposition induced by Fc variant anti-TREM2 antibodies. Fold change in C3b deposition of AL2p affinity matured variants with the listed Fc mutations relative to their parental IgG1 Fc variants.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P711-4.png)
Figure 5 shows the increase in activity of soluble anti-TREM2 antibody.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P711-5.png)
Figure 6 shows the increased activity of soluble anti-TREM2 antibodies.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P711-6.png)
Figure 7 shows sTREM2 secreted by primary human dendritic cells from donor 534 within 48 hours of incubation with anti-TREM2 or control antibody.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P711-7.png)
Figure 8 shows that after incubation of primary human dendritic cells from donor 534 with anti-TREM2 or control antibody, there was no change in cell number.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P711-8.png)
Figure 9 shows plasma sTREM2 as a percentage of baseline levels following a single injection of 15 mg/kg of the TREM2 antibodies AL2p-47 huIgG1 , AL2p-47 huIgG1 ASPSEG, AL2p-58 huIgG1 , or control huIgG1.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P711-9.png)
Figure 10 depicts increased viability (increased cellular ATP) after stimulation of primary human macrophages.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P711-10.png)
Figure 11 shows Western blot analysis of Dapl2 phosphorylation in WT or TREM2 Bac-Tg mouse peritoneal macrophages treated with AL2p-58 huIgG1 , AL2p-58 huIgG1 PSEG or control huIgG1.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P711-11.png)
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