Mouse Anti-GAT-1 Monoclonal Antibody (CBP2269)

[CAT#: NAB2010195LS]

Anti-GAT-1 Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Human; Mouse; Rat

Applications:: WB

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Product Overview

Description

SLC6A1 is the gene that encodes GABA transporter 1 (GAT1) and functions as the major presynaptic protein in neurons involved in the removal of excessive GABA from the synaptic cleft and the extrasynaptic space. Diseases associated with GAT1 include neurodevelopmental disorders such as schizophrenia and seizure.

Immunogen

KLH-conjugated C-terminal peptide of mouse SLC6A1.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2269

Applications

Application Notes

WB (2.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

GABA Transporter 1

Official Name

SLC6A1

Full Name

Sodium and chloride dependent GABA transporter 1

Alternative Names

GABATHG; GABATR; GABT 1; GABT1; GAT-1; GAT1

Gene ID

6529(Human); 232333(Mouse); 79212(Rat)

Uniprot ID

P30531(Human); P31648(Mouse); P23978(Rat)

References

1. Zafar S, et al. 2018. Front Chem. 6:397.
2. Lie MEK, et al. 2017. Adv. Neurobiol. 16:137-167.
3. Zhou Y, Danbolt NC. 2013. Front Endocrinol (Lausanne). 4:165.

Publications