Mouse Anti-LOX-1 Monoclonal Antibody (CBP2587)

Product Overview

Description

Mouse anti-human LOX-1 (soluble) antibody, recognizes the lectin-like oxidized low-density lipoprotein (LDL) receptor (LOX-1), which is a 31kDa protein of the C-type lectin superfamily. This receptor mediates the recognition, internalization and degradation of oxidized LDL. It is a type II membrane protein with a typical C-type lectin structure at the C-terminus outside the cell, which can recognize ligands. The activation of LOX-1 by oxidized LDL can cause endothelial cell changes, such as reducing the release of nitric oxide and increasing the expression of adhesion molecules. LOX-1 also binds activated platelets and apoptotic cells. The expression of LOX-1 is induced by pro-atherosclerotic conditions such as hyperlipidemia, hypertension and diabetes, and therefore seems to promote the pathogenesis of vascular diseases, especially atherosclerosis. It can be cleaved by an unknown protease in the extracellular proximal membrane region to release the soluble form of LOX-1 (aa58-273), which is recognized by the mouse anti-human LOX-1 (soluble) antibody clone LOX19-22.

Immunogen

Recombinant soluble LOX-1 expressed in E. coli.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2587

Applications

ELISA; WB

Relevant Diseases

Alzheimer's Disease; Neurodegenerative Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.09% Sodium Azide

Preservatives

YES

Concentration

1 mg/ml

Purification

Protein A

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

OLR1

Official Name

OLR1

Full Name

Oxidized Low Density Lipoprotein Receptor 1

Alternative Names

Oxidized Low Density Lipoprotein Receptor 1; C-Type Lectin Domain Family 8 Member A; Lectin-Type Oxidized LDL Receptor 1; CLEC8A; HLOX-1; LOX1; Oxidised Low Density Lipoprotein (Lectin-Like) Receptor 1; Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1; Oxidized Low-Density Lipoprotein Receptor 1, Soluble Form; Oxidized Low-Density Lipoprotein Receptor 1;