A-Z™ Pain Drug Discovery Platform

Overview of Pain Drug Discovery

Pain has been an active area of drug discovery, probably because there are many drugs, such as opiates, that have relatively pronounced results for many types of pain, but at the expense of many undesirable side effects. Opiates are highly addictive and have a high prevalence of substance use disorders in patients receiving chronic pain treatment. Currently, trying to find new painkiller drugs is an urgent task. The lack of suitable pain models is a key challenge in pain drug discovery. Most drug candidates show excellent analgesic effects in the preclinical stage but poor performance in clinical trials, which hinders drug discovery. To address this issue, Creative Biolabs has created many appropriate preclinical pain models. In addition, we have been committed to providing high-quality preclinical assay services to assist your pain drug discovery projects.

Preclinical Pain Models

We offer a wide range of cell models that are excellent tools for studying the efficacy of new therapies. Moreover, drug candidates must undergo rigorous animal testing to further evaluate their toxicity, metabolism, and efficacy before human trials. To characterize the potential analgesic properties of new compounds, Creative Biolabs has developed a series of experimental models of pain.

Fig.1 A-Z™ Pain Drug Discovery Platform.

❉ Cell Models

• Primary Neuronal Cell Culture Models
• Human iPSC Derived Neuronal Cell Culture Models
• Cell Line Models
• Transgenic Cell Line Models
• Organotypic Brain Slice Models

❉ Animal pain models

• Post-operative pain models
• Inflammatory pain models
• Cancer pain models
• Neuropathic pain models
• Wound healing models

Featured Assay Service Capabilities

❉ Preclinical in vitro Assay Services

• Cell proliferation and viability assays
• Drug combination assay
• Immunoassays
• Functional assays
• Toxicity assays

❉ In vivo imaging in Drug Discovery

• Optical imaging
• Multimodality imaging
• Calcium imaging

❉ Ex vivo services

• Histology Services
• Biomarker Analysis
• Ex Vivo Brain Slice Assay

Features of Our Services

At Creative Biolabs, we have a team of seasoned experts with our top-notch neuroscientists working on your project. In addition, our laboratory is equipped with cutting-edge scientific equipment and technology allowing fast and accurate collection of data. Most importantly, we offer the best in vitro and in vivo testing services that help you achieve your pain preclinical drug discovery goals. Our areas of expertise are still constantly expanding to meet the needs of different projects. We are confident to provide you with insightful data and guidance to help you make breakthroughs in your research.

If you have any difficulties with the pain drug discovery project, please contact us for details of our services and model selection advice.