AAVrh.10-APOE2 Viral Vector [Alzheimer's Disease]

[CAT#: NRP-0322-P2144]

Tracer Type:: Virus Vector/Partical

Applications:: Neural Tracing

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Description

APOE gene isoforms strongly affect the risk of developing Alzheimer's disease. APOE4 raises the risk, APOE2 reduces it. APOE4 is associated with acceleration of amyloid accumulation in the brain compared with other isoforms; E2 protects against pathology (e.g., Reiman et al., 2020). The rationale for gene therapy is to increase the expression of E2, and overcome the harmful effects of E4.

This AAVrh.10-APOE2 Viral Vector was designed to drive expression of human apolipoprotein E2 protein (APOE2) in the central nervous system. The serotype rh.10 adeno-associated virus with APOE2 cDNA is surgically injected into the fluid-filled space at the base of the brain.