Rat Anti-MAG Monoclonal Antibody (CBP2283)

Product Overview

Description

Myelin-associated glycoprotein (MAG) is a cell membrane glycoprotein and a member of the siglec (sialic acid-binding immunoglobulin-like lectins) family. MAG has two isoforms in myelinated structures in the nervous system. MAG is expressed on oligodendrocytes and Schwann cells and is believed to be involved in myelination during nerve regeneration. MAG knockout mice develop quite severe pathological abnormalities associated with myelin instability.

Immunogen

Purified MAG protein isolated from human central nervous system.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2b, κ

Clone Number

CBP2283

Applications

WB; IHC-P

Application Notes

WB (0.5-5.0 µg/mL); IHC-P (5.0-10.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

MAG

Official Name

MAG

Full Name

Myelin-associated glycoprotein

Alternative Names

MAG; GMA; S-SIGLEC-4A; SIGLEC4A; SPG75; myelin associated glycoprotein

Gene ID

4099(Human)

Uniprot ID

P20916(Human)

References

1. Dobersen MJ, et al. 1985. Neurochem Research. 4: 499
2. McKerracher L and Rosen KM. 2015. Front Mol Neurosci. 8: 51
3. Vallat JM, et al. 2016. Expert Rev Neurother. 9: 1111

Publications