iNeuMab™ Anti-Pan-Thyroid hormone receptor BBB Shuttle Antibody (NRZP-0423-ZP336)

Name: iNeuMab™ Anti-Pan-Thyroid hormone receptor BBB Shuttle Antibody (NRZP-0423-ZP336)
SKU: NRZP-0423-ZP336
Rating: 5 (1 reviews)

[CAT#: NRZP-0423-ZP336]

Species Reactivity:: Human; Rat; Mouse

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Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Pan-Thyroid hormone receptor BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-410 (full-length) of human Thyroid hormone receptor Alpha1 (also known as Nuclear receptor subfamily 1 group A member 1, V-erbA-related protein 7, c-erbA1, c-erbA-alpha, THRA, EAR7, ERBA1, NR1A1, THRA1 and Nr1a1, accession number P10827-2)
Mouse: 99% identity (407/410 amino acids identical)
Rat: 99% identity (407/410 amino acids identical)
~90% identity with Thyroid hormone receptor Alpha2
~75% identity with Thyroid hormone receptor Beta1 and Beta2