NeuroMab™ Anti-VDAC1 BBB Shuttle Antibody, Clone N152B/23

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-VDAC1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-283 (full-length) of human VDAC1 (also known as Voltage-dependent anion-selective channel protein 1, VDAC, VDAC5, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL/M, accession number P21796)
Mouse: 98% identity (279/283 amino acids identical)
Rat: 98% identity (279/283 amino acids identical)
>60% identity with VDAC2 and VDAC3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N152B/23

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with VDAC2 or VDAC3 (based on KO validation results)

Research Areas

Ion channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

VDAC1

Official Name

VDAC1

Full Name

VDAC1

Alternative Names

Voltage-dependent anion-selective channel protein 1; porin 31HL; porin 31HM; plasmalemmal porin; outer mitochondrial membrane protein porin 1; PORIN; VDAC-1

Uniprot ID

P21796

Product Pictures

Fig. 1 Immunoblot against membranes from livers of wild-type (WT) and VDAC1 knockout (KO) mice and brains of WT mice (MBM) and rat (RBM).

IHC

Fig. 2 Adult rat hippocampus immunohistochemistry.

Fig. 3 Array tomography immunofluorescence of 70 nm sections of LRWhite-embedded adult mouse hippocampus. Two consecutive sections labeled with N152B/23 (bottom) and DAPI (top), where low level autofluorescence reveals mitochondria appearing as brighter elongated structures within darker apical dendrites (arrows).

Publications