Product Overview

Description

The antibody is a mouse monoclonal antibody raised against RELN. It has been selected for its ability to recognize RELN in immunohistochemical staining and western blotting.

Immunogen

Recombinant Reelin (RELN)

Species Reactivity

Human

Clonality

Monoclonal

Isotype

IgG2b Kappa

Clone Number

CBP7959

Applications

WB; IHC; ICC; IP

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Concentration

1mg/mL

Purification

Protein A + Protein G affinity chromatography

Shipping

Refrigerated packaging

Storage

For long term storage, the product should be stored at -20°C or lower.

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Reelin

Official Name

RELN

Full Name

Reelin

Alternative Names

Reelin (RELN) [5] is a secreted large extracellular matrix glycoprotein that can help regulate neuronal migration and localization in the developing brain by controlling cell-cell interactions. In addition to playing an important role in early development; Reelin also continues to play a role in the adult brain. [6] It regulates synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. [7] [8] It also stimulates the development of dendrites [9] and dendritic spines [10] and regulates the continued migration of neuroblasts produced in adult neurogenesis sites (such as the subventricular and subgranular regions). It is found not only in the brain; but also in the liver; thyroid; adrenal glands; fallopian tubes; and breasts; and is also low in a range of anatomical regions. [11]