Neuropathology/Neurohistology Assay

Neurological diseases, which occur in the central and peripheral nervous systems, including Alzheimer's disease, stroke, and spinal cord injury, impose an incalculable burden and death on humans worldwide. Assessment of the pathophysiology and histology of neurological diseases will be key to designing research methods and understanding and managing possible long-term effects of the disease on patients with neurological disorders. Creative Biolabs provides neuropathology/neurohistology assay services to global neurobiological scientists to support your projects.

Neurohistology Services

Creative Biolabs is committed to providing time and cost-effective brain research products and services for preclinical research on the central nervous system, focusing on various types of neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's diseases, ischemic stroke, and motor neuron disease (MND) including amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease and spinal cord injury (SCI).

Creative Biolabs provides the most reliable histological service, including:

Tissue Sampling and Processing
H&E Staining
Whole Slide Imaging
Section Scanning
Immunohistochemical Services
Immunofluorescence Services
Clinical Pathology Service
Toxicologic Pathology Service
Ultramicropathology Services
Histopathological Evaluation Services

Features of our Services

Neurohistological and neuropathological services of the central nervous system (CNS)
Neural staining kits
High-throughput digital microscopic imaging and stereology-based quantitative morphology
GLP and non-GLP studies.

Neurohistopathology Assay Showcase

Assay #1: Impact of AL002c treatment on microglia clustering around plaques and Spp1 production.

Fig. 1 Representative confocal images of Alzheimer's mouse hippocampus. Iba1 microglia (green), TO-PRO3-stained nuclei (red), and methoxy-X04-labeled aβ plaques (blue). (Mustafa, 2020)

Assay #2: Neuropathology of dementia.

Fig. 2 Visualization of β-amyloid and hyperphosphorylated tau using immunohistochemical staining. (Klotz, 2021)

For 20 years, Creative Biolabs has been committed to cutting-edge biotechnology and has provided many scientific research services for global bioscientists with professional technology and expertise. Our state-of-the-art technology and high-quality service have received favorable comments from clients all over the world.

With extensive research experience, Creative Biolabs also helps our clients validate and develop the most cost-effective experimental designs and protocols. Technical support is provided throughout the research process. If you are interested in our service, please do not hesitate to contact us directly.

References

Mustafa, M.; et al. Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model. J Exp Med. 2020, 217(9), e20200785.
Klotz, S.; et al. Neuropathologie der Demenzen. Wien Med Wochenschr. 2021, 171(11-12): 257-273.

Case Studies

For Research Use Only. Not For Clinical Use.

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