Brain Tissue Clearing and Imaging Service
Based on our high-level research team and leading research platform, Creative Biolabs provides custom brain tissue clearing and imaging service to meet our customers' different purposes in scientific research and clinical trials. Our highly skilled scientists are ready to get started on your projects.
Why do you need tissue clearing?
The nervous system is by far the most complex organ, with probably hundreds of different cell types forming intricate circuits and networks, the organization of which is extremely difficult to understand from 2D slices. The emergence of tissue clearing has changed this dilemma, tissue clearing refers to a collection of techniques that render biological samples transparent that enable the deep imaging of large tissue volumes using light microscopy approaches. These techniques allow you to avoid time consuming tissue sectioning approaches that can introduce artefacts and examine biological tissues in their native, 3D state.
Our Brain Tissue Clearing Service
At Creative Biolabs, our mature tissue clearing technology has been used to render tissue samples, organoids, microtissues optically transparent or "cleared". We combine tissue clearing with light-sheet microscopy which allowing us to perform 3D imaging of intact tissues, such as the entire mouse brains and spinal cords, and even some entire organisms. Our tissue clearing technology allows you to better observe the extent of central nervous system deterioration in some animal models of neurological diseases. All you need to do is trust us. Our state-of-the-art technology and excellent researchers will customize the best brain tissue clearing solution for you.
- Customized intact full service
Fig1. Whole mouse brain clearing.
You send us your experimental animals, and Creative Biolabs can ensure the preservation of fluorescent signal, sample integrity, and higher clearing performance.
- Tissue clearing process
Fig.2 Tissue clearing process.
Upon receiving your samples, Creative Biolabs technicians allow CNS-wide identification of vulnerable circuits and cell types using tissue clearing; and nanoscale imaging using expansion microscopy.
Our Brain Tissue Imaging Service
At Creative Biolabs, there are multiple state-of-the-art imaging systems. Cleared samples can be imaged using epifluorescence, confocal and two-photon microscopes. These imaging systems allow high-speed and high-resolution imaging of large specimens, such as a whole mouse brain and even intact human organs.
Fig. 3 Imaging of the mouse brain vasculature.
- Applications of brain imaging service
Specifically, our brian imaging services can be used for the following research projects. If you need to image tissue not shown below, please directly contact us.
| Applications | Clearing time |
| Imaging of spinal cord injury. | 2 days |
| Visualization of vasculature in entire brains. | 7 days |
| Imaging of tau neuropathology. | 7-14 days |
| Detection of amyloid plaques in brain tissue. | 1-3 weeks |
| Visualization of detailed neuronal morphology. | 7-14 days |
| Identification of fragmented nigrostriatal axons in PD mice. | 1-3 weeks |
| Visualization of Lewy pathology in brain. | 1-3 weeks |
| Astrocytic imaging in brain epilepsy. | 1-2 days |
Table1. Tissue imaging applications.
Creative Biolabs is a leading supplier of custom brain tissue clearing and imaging solutions to our partners worldwide. We are pleased to share our extensive expertise in brain-clearing technology to facilitate our clients’ research and project development. If you are looking for a customized service, please don't hesitate to contact us directly. We can design and customize your project and generate the exact brain tissue clearing and Imaging solutions you need.
