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Creative Biolabs

NoGeneST™ Anti-CCL2 Aptamer, aCCL2 aptamer-2

[CAT#: NRYF-0625-HZ70]

A highly stable, mirror-image L-RNA aptamer (Spiegelmer) that neutralizes the pro-inflammatory chemokine CCL2.

Target:
CCL2
Type:
RNA

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Product Overview

Description

This therapeutic agent is a pegylated L-RNA aptamer, a class of molecules known as Spiegelmers. This mirror-image configuration provides exceptional resistance to degradation by natural enzymes, enhancing its in vivo stability. The aptamer is engineered to bind with high affinity to the chemokine CCL2, preventing it from activating its receptor, CCR2. This blockade is designed to inhibit the recruitment of inflammatory monocytes, making it a promising strategy for treating chronic inflammatory and fibrotic diseases.

Type

RNA
Properties

Size

1 mg; 5 mg; 10 mg

Appearance

Supplied as a lyophilized white to off-white solid.

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only
Target Details

Target

CCL2

Full Name

Chemokine (C-C motif) ligand 2

Alternative Names

Monocyte chemoattractant protein-1 (MCP-1); Monocyte chemotactic and activating factor (MCAF); Small inducible cytokine A2 (SCYA2)

Gene ID

6347

Uniprot ID

P13500

Target Overview

Chemokine (C-C motif) ligand 2 (CCL2), also widely known as Monocyte Chemoattractant Protein-1 (MCP-1), is a potent pro-inflammatory chemokine. It plays a pivotal role in the innate immune response by orchestrating the migration and infiltration of monocytes, memory T-lymphocytes, and natural killer (NK) cells. Secreted by a variety of cell types upon inflammatory stimulus, CCL2 exerts its effect by binding to the G protein-coupled receptor CCR2. The CCL2/CCR2 signaling axis is a fundamental pathway in the pathogenesis of numerous diseases characterized by chronic inflammation, including diabetic nephropathy, rheumatoid arthritis, atherosclerosis, and fibrosis. Its central role in recruiting inflammatory leukocytes to damaged tissues makes CCL2 a high-priority target for therapeutic intervention.
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