NoGeneST™ Anti-CCL2 Aptamer, aCCL2 aptamer-1 sodium

Name: NoGeneST™ Anti-CCL2 Aptamer, aCCL2 aptamer-1 sodium
SKU: NRYF-0625-HZ11
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ11]

A highly stable, pegylated L-RNA aptamer (Spiegelmer) that functions as a potent and specific inhibitor of the pro-inflammatory chemokine CCL2 (MCP-1), offering a targeted approach to mitigating monocyte-driven inflammation.

Target:: CCL2

Type:: RNA

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Product Overview

Description

This therapeutic agent is a state-of-the-art Spiegelmer, consisting of a synthetically produced L-ribonucleic acid (L-RNA) aptamer conjugated to a polyethylene glycol (PEG) polymer. The use of a mirror-image L-RNA configuration renders the molecule exceptionally resistant to degradation by naturally occurring D-RNA specific nucleases, which dramatically enhances its in vivo stability and pharmacokinetic profile. The aptamer is engineered for high-affinity binding to Chemokine (C-C motif) ligand 2 (CCL2), effectively neutralizing its biological activity. By preventing CCL2 from engaging with its cognate receptor CCR2, this therapeutic blocks the key signaling pathway responsible for recruiting monocytes and macrophages to sites of inflammation and tissue damage. This targeted mechanism makes it a promising candidate for treating a range of chronic inflammatory and fibrotic diseases.

Type

RNA

Properties

Size

1 mg; 5 mg; 10 mg

Appearance

Supplied as a lyophilized white to off-white solid.

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

CCL2

Full Name

Chemokine (C-C motif) ligand 2

Alternative Names

Monocyte chemoattractant protein-1 (MCP-1); Monocyte chemotactic and activating factor (MCAF); Small inducible cytokine A2 (SCYA2)

Gene ID

6347

Uniprot ID

P13500

Target Overview

Chemokine (C-C motif) ligand 2 (CCL2), also widely known as Monocyte Chemoattractant Protein-1 (MCP-1), is a potent pro-inflammatory chemokine. It plays a pivotal role in the innate immune response by orchestrating the migration and infiltration of monocytes, memory T-lymphocytes, and natural killer (NK) cells. Secreted by a variety of cell types upon inflammatory stimulus, CCL2 exerts its effect by binding to the G protein-coupled receptor CCR2. The CCL2/CCR2 signaling axis is a fundamental pathway in the pathogenesis of numerous diseases characterized by chronic inflammation, including diabetic nephropathy, rheumatoid arthritis, atherosclerosis, and fibrosis. Its central role in recruiting inflammatory leukocytes to damaged tissues makes CCL2 a high-priority target for therapeutic intervention.

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