NoGeneST™ Anti-VWF Aptamer, aVWF aptamer-2 sodium

Name: NoGeneST™ Anti-VWF Aptamer, aVWF aptamer-2 sodium
SKU: NRYF-0625-HZ14
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ14]

Effectively inhibits von Willebrand factor (VWF)

Target:: VWF

Type:: DNA

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Product Overview

Description

This compound consists of a high-affinity nucleic acid aptamer covalently attached to polyethylene glycol (PEG). It functions as a potent and selective antagonist of the von Willebrand factor (VWF) A1 domain, sterically blocking its interaction with platelet glycoprotein Ibα (GPIbα). This inhibition prevents shear stress-induced platelet adhesion and aggregation, particularly effective against arterial thrombosis formation. The PEGylation enhances pharmacokinetic properties including plasma half-life extension and reduced renal clearance.

Type

DNA

Properties

Size

1 mg; 5 mg; 10 mg

Appearance

Supplied as a lyophilized white to off-white solid.

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

VWF

Full Name

Von Willebrand Factor

Alternative Names

Factor VIII related antigen

Gene ID

7450

Uniprot ID

P04275

Target Overview

Von Willebrand Factor (VWF) is a large, multimeric glycoprotein that plays a central and critical role in hemostasis (the cessation of bleeding). It performs two primary functions in the bloodstream: first, it acts as a molecular bridge, mediating the adhesion of platelets to exposed subendothelial collagen at sites of vascular injury, a crucial initial step in forming a platelet plug. Second, it serves as a carrier protein for Coagulation Factor VIII, binding to it and protecting it from premature degradation in the circulation. The size and adhesive activity of VWF multimers are tightly regulated, and dysregulation of VWF function can lead to either bleeding disorders (like von Willebrand disease) or pathological thrombosis.

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