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Oligodendrocyte Marker Related Research Reagents

Oligodendrocyte Markers

Oligodendrocytes (ODs) are glial cells in the central nervous system (CNS) that form the myelin sheath of axons to support rapid nerve conduction. OD also contributes to neuroplasticity and provides nutritional support for neurons. Each OD can interact with multiple axons and has the ability to quickly update its myelin sheath. Each myelin sheath of oligodendrocytes has up to 50 independent axons. As a result, OD has a high metabolic rate and is very susceptible to oxidative stress. OD is highly sensitive to pro-inflammatory molecules produced during inflammation and responds by producing low-quality myelin. In addition, OD can also affect neuronal survival, axon transport, axon caliber, and ion channel aggregation along the axon. OD damage and dysfunction are responsible for the development of many diseases and conditions, including multiple sclerosis, schizophrenia, and bipolar disorder.

Each stage of oligodendrocyte differentiation and maturation can be monitored by the specific morphology markers, including the most common maturation stage markers CNPase, Olig2 and oligodendrocyte marker O4. Creative Biolabs provides a series of research tools needed to study the development, maturation and function of oligodendrocytes. Our product portfolio includes monoclonal antibodies, polyclonal antibodies, labeled antibodies, proteins, analytical kits, and small molecule activators and inhibitors.

Summary of Oligodendrocyte Markers Provided by Creative Biolabs

Oligodendrocyte Precursor Cell Markers

Subcellular Localization Markers
Nuclear NKX2.2
Olig2
SOX10
Cytoplasmic Olig2  
Cell Surface A2B5
NG2/MCSP
Oligodendrocyte Marker O4
PDGF Rα

Immature Oligodendrocyte Markers

Subcellular Localization Markers
Cytoplasmic CNPase
Cell Surface Oligodendrocyte Marker O1 Oligodendrocyte Marker O4

Non-Myelinating Oligodendrocyte Markers

Subcellular Localization Markers
Cytoplasmic CNPase
Nogo-A
APC
Cell Surface Oligodendrocyte Marker O1
Myelin PLP
Oligodendrocyte Marker O4

Myelinating Oligodendrocyte Markers

Subcellular Localization Markers
Cytoplasmic CNPase
TPPP/p25
MBP
APC
OMgp
Nogo-A
Cell Surface Caspr2
MAG/Siglec-4a
MOG
Myelin PLP
For Research Use Only. Not For Clinical Use.

Target

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