Oligodendrocyte Marker Related Research Reagents
Oligodendrocytes (ODs) are glial cells in the central nervous system (CNS) that form the myelin sheath of axons to support rapid nerve conduction. OD also contributes to neuroplasticity and provides nutritional support for neurons. Each OD can interact with multiple axons and has the ability to quickly update its myelin sheath. Each myelin sheath of oligodendrocytes has up to 50 independent axons. As a result, OD has a high metabolic rate and is very susceptible to oxidative stress. OD is highly sensitive to pro-inflammatory molecules produced during inflammation and responds by producing low-quality myelin. In addition, OD can also affect neuronal survival, axon transport, axon caliber, and ion channel aggregation along the axon. OD damage and dysfunction are responsible for the development of many diseases and conditions, including multiple sclerosis, schizophrenia, and bipolar disorder.
Each stage of oligodendrocyte differentiation and maturation can be monitored by the specific morphology markers, including the most common maturation stage markers CNPase, Olig2 and oligodendrocyte marker O4. Creative Biolabs provides a series of research tools needed to study the development, maturation and function of oligodendrocytes. Our product portfolio includes monoclonal antibodies, polyclonal antibodies, labeled antibodies, proteins, analytical kits, and small molecule activators and inhibitors.
Summary of Oligodendrocyte Markers Provided by Creative Biolabs
Oligodendrocyte Precursor Cell Markers
| Subcellular Localization | Markers | |
| Nuclear |
NKX2.2 Olig2 |
SOX10 |
| Cytoplasmic | Olig2 | |
| Cell Surface |
A2B5 NG2/MCSP |
Oligodendrocyte Marker O4 PDGF Rα |
Immature Oligodendrocyte Markers
| Subcellular Localization | Markers | |
| Cytoplasmic | CNPase | |
| Cell Surface | Oligodendrocyte Marker O1 | Oligodendrocyte Marker O4 |
Non-Myelinating Oligodendrocyte Markers
| Subcellular Localization | Markers | |
| Cytoplasmic |
CNPase Nogo-A |
APC |
| Cell Surface |
Oligodendrocyte Marker O1 Myelin PLP |
Oligodendrocyte Marker O4 |
Myelinating Oligodendrocyte Markers
| Subcellular Localization | Markers | |
| Cytoplasmic |
CNPase TPPP/p25 MBP |
APC OMgp Nogo-A |
| Cell Surface |
Caspr2 MAG/Siglec-4a |
MOG Myelin PLP |
Target
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NG2 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated
CNPase Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-P
- Conjugation:
- Unconjugated
CNPase Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB
- Conjugation:
- Unconjugated
Oligodendrocyte Specific Protein Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- FCM; WB
- Conjugation:
- Unconjugated
nSMase Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IP
- Conjugation:
- Unconjugated
Myelin Basic Protein Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-P; Protein Array
- Conjugation:
- Unconjugated
PMP22 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- IMC™; WB; IHC-P; IHC-Fr
- Conjugation:
- Unconjugated
Caspr Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- IMC™; WB; IHC-P; IHC-Fr
- Conjugation:
- Unconjugated
Caspr2/CNTNAP2 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-P
- Conjugation:
- Unconjugated
Myelin Basic Protein Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB
- Conjugation:
- Unconjugated
Myelin PLP Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Cow
- Applications:
- IHC-Fr; WB; ICC; IF; IHC
- Conjugation:
- Unconjugated
Myelin Basic Protein Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB; IHC-P
- Conjugation:
- Unconjugated
APC Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat; Human; Monkey
- Applications:
- FCM; IHC-P; ICC; IF; IHC-Fr
- Conjugation:
- APC
Myelin PLP Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- IHC-P; IP
- Conjugation:
- Unconjugated
Caspr2/CNTNAP2 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IHC-P
- Conjugation:
- Unconjugated
Caspr Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IHC-P; ICC; IF
- Conjugation:
- Unconjugated
PMP22 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB; IHC-P; ICC; IF; IP; FCM
- Conjugation:
- Unconjugated
Myelin Basic Protein Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Sheep; Rabbit; Goat; Human
- Applications:
- WB; ELISA; IHC-P; IHC-Fr; ICC; IF; FCM; IHC-Fr
- Conjugation:
- Unconjugated
APC Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IHC-P; IP; FCM; ICC
- Conjugation:
- Unconjugated
Myelin Basic Protein Human Monoclonal Antibody
- Host Species:
- Human
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- ELISA; WB; ICC; IF; IHC-P
- Conjugation:
- Unconjugated
Oligodendrocytes
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- IHC; WB; IF
Oligodendrocytes
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- IHC; WB
Oligodendrocytes
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- IHC; WB
Oligodendrocytes
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- IHC; WB
Oligodendrocytes
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- IHC; WB
- Applications:
- ELISA
- Applications:
- ELISA
Mouse Monoclonal Antibody to NRG1
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
Rabbit Monoclonal Antibody to NG2
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB; ICC; IF; IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
Rabbit Monoclonal Antibody to Myelin Basic Protein
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Human
- Applications:
- WB; IHC-P; IHC-Fr
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
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- iNeuMab™ Anti-CD32b Antibody (NRP-0422-P1803) (Cat#: NRP-0422-P1803)
- Human Microglia Cell Line HMC3, Immortalized (Cat#: NCL-2108P38)
- Human Astrocytes, Immortalized (Cat#: NCL-2105-P182-AM)
- Mouse Retinal Ganglion Cell Line RGC-5 (Cat#: NCL2110P154)
- Mouse Microglia Cell Line BV-2, Immortalized (Cat#: NCL2110P153)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- Mouse Glioma Cell Line GL261 (Cat#: NCL-2108P28)
- iNeu™ Human Motor Neurons (Cat#: NCL-2103-P71)
- Human Brain Vascular Adventitial Fibroblasts (Cat#: NCL-21P6-014)
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- Rat Muller Cell (Cat#: NCL2110P040)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
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- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
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- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
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- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
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- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
