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Microglia Marker Related Research Reagents

Microglia are resident macrophages in the central nervous system (CNS) and play an immune defense role. They exist in a static state in healthy CNS tissues, actively investigate the surrounding areas after being injured or infected, and can be quickly activated in response to environmental changes.

Once a threat is detected, the microglia will undergo morphological changes. Activated microglia are divided into two states, M1 and M2, based on their morphology. M1 microglia are the cells that initially respond to injury and cause proinflammatory responses. Cytokines, such as IFN-γ and TNF-α, as well as bacteria and cell debris, will polarize microglia to the M1 phenotype. M2 microglia are "alternatively" activated microglia, also recognized as anti-inflammatory microglia, that can promote the regression of neuroinflammation and stimulate tissue repair.

Schematic description of microglial activation and polarization in the central nervous system. Fig.1 Schematic description of microglial activation and polarization in the central nervous system.

Summary of Microglia Markers Provided by Creative Biolabs

Steady-State Microglia Markers

Subcellular Localization Markers
Cytoplasmic AIF-1/Iba1
Cell Surface CD11b/Integrin aM
CD45
CX3CR1
F4/80/EMR1
FcγRI/CD64
FCRL4/FcRH4
M-CSF R/CD115
Mer
P2Y12/P2RY12
Siglec-H
TMEM119
Secreted BDNF IGF-I BDNF IGF-I

M1 Microglia Markers

Subcellular Localization Markers
Cytoplasmic iNOS COX-2
Cell Surface B7-1/CD80
B7-2/CD86
CD11b/Integrin aM
CD36/SR-B3
CD40/TNFRSF5
CD68/SR-D1
Fcg RII/CD32
Fcg RIII/CD16
HLA-DR
MHC Class II
Secreted CCL2/JE/MCP-1
CCL4/MIP-1b
CXCL1/GROa/KC/CINC-1
CXCL10/IP-10
IFN-g
IL-1b/IL-1F2
IL-6
IL-12
IL-17/IL-17A
IL-18/IL-1F4
Nitric Oxide
TNF-a

M2 Microglia Markers

Subcellular Localization Markers
Nuclear PPARg/NR1C3
Cytoplasmic Arginase 1/ARG1 Transglutaminase 2/TGM2 Arginase 1/ARG1 Transglutaminase 2/TGM2
Cell Surface CD163
CLEC10A/CD301
DC-SIGN/CD209
HLA-DR
MHC Class II
MMR/CD206
Siglec-3/CD33
SR-AI
TREM-2
Secreted BDNF
FIZZ1/RELMa
IGF-I
IL-1ra/IL-1F3
IL-4
IL-10
IL-13
TGF-b
YM1/Chitinase 2-like 3

Creative Biolabs provides a series of research tools needed to study the activation status of different microglia. Our product portfolio includes monoclonal antibodies, polyclonal antibodies, labeled antibodies, proteins, analytical kits, and small molecule activators and inhibitors.

For Research Use Only. Not For Clinical Use.

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