Microglia Marker Related Research Reagents
Microglia are resident macrophages in the central nervous system (CNS) and play an immune defense role. They exist in a static state in healthy CNS tissues, actively investigate the surrounding areas after being injured or infected, and can be quickly activated in response to environmental changes.
Once a threat is detected, the microglia will undergo morphological changes. Activated microglia are divided into two states, M1 and M2, based on their morphology. M1 microglia are the cells that initially respond to injury and cause proinflammatory responses. Cytokines, such as IFN-γ and TNF-α, as well as bacteria and cell debris, will polarize microglia to the M1 phenotype. M2 microglia are "alternatively" activated microglia, also recognized as anti-inflammatory microglia, that can promote the regression of neuroinflammation and stimulate tissue repair.
Fig.1 Schematic description of microglial activation and polarization in the central nervous system.
Summary of Microglia Markers Provided by Creative Biolabs
Steady-State Microglia Markers
Subcellular Localization | Markers | |
Cytoplasmic | AIF-1/Iba1 | |
Cell Surface |
CD11b/Integrin aM CD45 CX3CR1 F4/80/EMR1 FcγRI/CD64 FCRL4/FcRH4 |
M-CSF R/CD115 Mer P2Y12/P2RY12 Siglec-H TMEM119 |
Secreted | BDNF IGF-I | BDNF IGF-I |
M1 Microglia Markers
Subcellular Localization | Markers | |
Cytoplasmic | iNOS | COX-2 |
Cell Surface |
B7-1/CD80 B7-2/CD86 CD11b/Integrin aM CD36/SR-B3 CD40/TNFRSF5 |
CD68/SR-D1 Fcg RII/CD32 Fcg RIII/CD16 HLA-DR MHC Class II |
Secreted |
CCL2/JE/MCP-1 CCL4/MIP-1b CXCL1/GROa/KC/CINC-1 CXCL10/IP-10 IFN-g IL-1b/IL-1F2 |
IL-6 IL-12 IL-17/IL-17A IL-18/IL-1F4 Nitric Oxide TNF-a |
M2 Microglia Markers
Subcellular Localization | Markers | |
Nuclear | PPARg/NR1C3 | |
Cytoplasmic | Arginase 1/ARG1 Transglutaminase 2/TGM2 | Arginase 1/ARG1 Transglutaminase 2/TGM2 |
Cell Surface |
CD163 CLEC10A/CD301 DC-SIGN/CD209 HLA-DR MHC Class II |
MMR/CD206 Siglec-3/CD33 SR-AI TREM-2 |
Secreted |
BDNF FIZZ1/RELMa IGF-I IL-1ra/IL-1F3 IL-4 |
IL-10 IL-13 TGF-b YM1/Chitinase 2-like 3 |
Creative Biolabs provides a series of research tools needed to study the activation status of different microglia. Our product portfolio includes monoclonal antibodies, polyclonal antibodies, labeled antibodies, proteins, analytical kits, and small molecule activators and inhibitors.


CD11b Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Pig
- Applications:
- FCM
- Conjugation:
- Unconjugated

CD11b Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated

CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated

CD45 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- FCM
- Conjugation:
- Unconjugated

CD11b Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- FCM
- Conjugation:
- Unconjugated

CD11b Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated

CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated

CD45.1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse
- Applications:
- FCM; ICC; IF; Other
- Conjugation:
- Unconjugated

CD11b Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM; ICC; IF
- Conjugation:
- Unconjugated

CD11b Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated

F4/80 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- IHC-Fr; FCM; IHC-P
- Conjugation:
- Unconjugated

MRP8 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- WB
- Conjugation:
- Unconjugated

pan Macrophage Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat
- Applications:
- IHC-Fr; FCM
- Conjugation:
- Unconjugated

CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-P
- Conjugation:
- Unconjugated

CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat
- Applications:
- FCM
- Conjugation:
- Unconjugated

CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated

CD45 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated

CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-P
- Conjugation:
- Unconjugated

CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-Fr; IHC-P
- Conjugation:
- Unconjugated

MRP8 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; ELISA; FCM; IHC-P
- Conjugation:
- Unconjugated

Iba1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- Protein Array; IHC-P
- Conjugation:
- Unconjugated

CD45 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- IP; ICC; IF; FCM; IHC-Fr
- Conjugation:
- Unconjugated

MRP8 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- Sandwich ELISA
- Conjugation:
- Unconjugated

MRP8 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM; IHC-P; ELISA; WB
- Conjugation:
- Unconjugated

CD11b Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; IHC-P; Protein Array
- Conjugation:
- Unconjugated

CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- FCM; ICC; IF; IHC-Fr
- Conjugation:
- Unconjugated

MRP8 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB; IP
- Conjugation:
- Unconjugated

CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IP; IHC-Fr; IHC-P; WB; FCM; ICC; IF
- Conjugation:
- Unconjugated

Iba1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- Protein Array; IHC-P
- Conjugation:
- Unconjugated

CD11b Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB; IHC-P
- Conjugation:
- Unconjugated
- iNeuMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- iNeuMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- iNeuMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- iNeuMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- iNeuMab™ Anti-F-Spondin/SPON1 Antibody, Clone 3F4 (Cat#: NRZP-0822-ZP4740)
- Rat Microglia Cell Line HAPI, Immortalized (Cat#: NCL2110P015)
- iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) (Cat#: NCL-2103-P49)
- Rat Retinal Muller Cell Line, Immortalized (Cat#: NCL-21P6-192)
- iNeu™ Human Schwann Cell (Cat#: NCL-2103-P63)
- Human Astrocytes, Immortalized (Cat#: NCL-2105-P182-AM)
- Human Retinal Epithelial Cell ARPE-19 (Cat#: NCL2110P069)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- Mouse Midbrain Dopaminergic Neuron Cell MN9D (Cat#: NCL2110P059)
- Mouse Microglia Cell Line BV-2, Immortalized (Cat#: NCL2110P153)
- Green Fluorescent Alpha-synuclein Cell Line (Cat#: NCL2110P209)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)