Microglia Marker Related Research Reagents
Microglia are resident macrophages in the central nervous system (CNS) and play an immune defense role. They exist in a static state in healthy CNS tissues, actively investigate the surrounding areas after being injured or infected, and can be quickly activated in response to environmental changes.
Once a threat is detected, the microglia will undergo morphological changes. Activated microglia are divided into two states, M1 and M2, based on their morphology. M1 microglia are the cells that initially respond to injury and cause proinflammatory responses. Cytokines, such as IFN-γ and TNF-α, as well as bacteria and cell debris, will polarize microglia to the M1 phenotype. M2 microglia are "alternatively" activated microglia, also recognized as anti-inflammatory microglia, that can promote the regression of neuroinflammation and stimulate tissue repair.
Fig.1 Schematic description of microglial activation and polarization in the central nervous system.
Summary of Microglia Markers Provided by Creative Biolabs
Steady-State Microglia Markers
| Subcellular Localization | Markers | |
| Cytoplasmic | AIF-1/Iba1 | |
| Cell Surface |
CD11b/Integrin aM CD45 CX3CR1 F4/80/EMR1 FcγRI/CD64 FCRL4/FcRH4 |
M-CSF R/CD115 Mer P2Y12/P2RY12 Siglec-H TMEM119 |
| Secreted | BDNF IGF-I | BDNF IGF-I |
M1 Microglia Markers
| Subcellular Localization | Markers | |
| Cytoplasmic | iNOS | COX-2 |
| Cell Surface |
B7-1/CD80 B7-2/CD86 CD11b/Integrin aM CD36/SR-B3 CD40/TNFRSF5 |
CD68/SR-D1 Fcg RII/CD32 Fcg RIII/CD16 HLA-DR MHC Class II |
| Secreted |
CCL2/JE/MCP-1 CCL4/MIP-1b CXCL1/GROa/KC/CINC-1 CXCL10/IP-10 IFN-g IL-1b/IL-1F2 |
IL-6 IL-12 IL-17/IL-17A IL-18/IL-1F4 Nitric Oxide TNF-a |
M2 Microglia Markers
| Subcellular Localization | Markers | |
| Nuclear | PPARg/NR1C3 | |
| Cytoplasmic | Arginase 1/ARG1 Transglutaminase 2/TGM2 | Arginase 1/ARG1 Transglutaminase 2/TGM2 |
| Cell Surface |
CD163 CLEC10A/CD301 DC-SIGN/CD209 HLA-DR MHC Class II |
MMR/CD206 Siglec-3/CD33 SR-AI TREM-2 |
| Secreted |
BDNF FIZZ1/RELMa IGF-I IL-1ra/IL-1F3 IL-4 |
IL-10 IL-13 TGF-b YM1/Chitinase 2-like 3 |
Creative Biolabs provides a series of research tools needed to study the activation status of different microglia. Our product portfolio includes monoclonal antibodies, polyclonal antibodies, labeled antibodies, proteins, analytical kits, and small molecule activators and inhibitors.
For Research Use Only. Not For Clinical Use.
Related Products
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Mouse Anti-ITGAM Monoclonal Antibody (CBP7111) [CAT#: NAB-0720-Z9273]
CD11b Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Pig
- Applications:
- FCM
- Conjugation:
- Unconjugated
Mouse Anti-ITGAM Monoclonal Antibody (CBP7110) [CAT#: NAB-0720-Z9272]
CD11b Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated
Mouse Anti-PTPRC Monoclonal Antibody (CBP7109) [CAT#: NAB-0720-Z9268]
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Alexa Fluor® 488
NeuroMab™ Rat Anti-PTPRC Monoclonal Antibody (CBP7108) [CAT#: NAB-0720-Z9244]
CD45 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- FCM
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3439
Rat Anti-ITGAM Monoclonal Antibody (CBP7107) [CAT#: NAB-0720-Z9231]
CD11b Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- FCM
- Conjugation:
- Unconjugated
Mouse Anti-ITGAM Monoclonal Antibody (CBP7106) [CAT#: NAB-0720-Z9218]
CD11b Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- PE
Mouse Anti-PTPRC Monoclonal Antibody (CBP7105) [CAT#: NAB-0720-Z9206]
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated
NeuroMab™ Mouse Anti-PTPRC Monoclonal Antibody (CBP7104) [CAT#: NAB-0720-Z9201]
CD45.1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse
- Applications:
- FCM; ICC; IF; Other
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3438
Mouse Anti-ITGAM Monoclonal Antibody (CBP7103) [CAT#: NAB-0720-Z9200]
CD11b Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM; ICC; IF
- Conjugation:
- Unconjugated
NeuroMab™ Mouse Anti-ITGAM Monoclonal Antibody (CBP7102) [CAT#: NAB-0720-Z9183]
CD11b Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3437
NeuroMab™ Rat Anti-ADGRE1 Monoclonal Antibody (CBP7101) [CAT#: NAB-0720-Z9172]
F4/80 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- IHC-Fr; FCM; IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3436
Rat Anti-ABCC11 Monoclonal Antibody (CBP7100) [CAT#: NAB-0720-Z9161]
MRP8 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- WB
- Conjugation:
- Unconjugated
Mouse Anti-pan Macrophage Monoclonal Antibody (CBP7099) [CAT#: NAB-0720-Z9157]
pan Macrophage Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat
- Applications:
- IHC-Fr; FCM
- Conjugation:
- Unconjugated
Mouse Anti-PTPRC Monoclonal Antibody (CBP7098) [CAT#: NAB-0720-Z9155]
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-P
- Conjugation:
- Unconjugated
NeuroMab™ Mouse Anti-PTPRC Monoclonal Antibody (CBP7097) [CAT#: NAB-0720-Z9154]
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat
- Applications:
- FCM
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3435
NeuroMab™ Mouse Anti-PTPRC Monoclonal Antibody (CBP7096) [CAT#: NAB-0720-Z9150]
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3434
Rat Anti-PTPRC Monoclonal Antibody (CBP7095) [CAT#: NAB-0720-Z9149]
CD45 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Human
- Applications:
- FCM
- Conjugation:
- Unconjugated
Mouse Anti-PTPRC Monoclonal Antibody (CBP7094) [CAT#: NAB-0720-Z9146]
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-P
- Conjugation:
- Unconjugated
Mouse Anti-PTPRC Monoclonal Antibody (CBP7093) [CAT#: NAB-0720-Z9139]
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-Fr; IHC-P
- Conjugation:
- Unconjugated
Mouse Anti-ABCC11 Monoclonal Antibody (CBP7092) [CAT#: NAB-0720-Z9137]
MRP8 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; ELISA; FCM; IHC-P
- Conjugation:
- Unconjugated
NeuroMab™ Mouse Anti-AIF1 Monoclonal Antibody (CBP7091) [CAT#: NAB-0720-Z9136]
Iba1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- Protein Array; IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3433
Rat Anti-PTPRC Monoclonal Antibody (CBP7090) [CAT#: NAB-0720-Z9131]
CD45 Rat Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- IP; ICC; IF; FCM; IHC-Fr
- Conjugation:
- Unconjugated
Rabbit Anti-ABCC11 Monoclonal Antibody (CBP7089) [CAT#: NAB-0720-Z9130]
MRP8 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- Sandwich ELISA
- Conjugation:
- Unconjugated
Mouse Anti-ABCC11 Monoclonal Antibody (CBP7088) [CAT#: NAB-0720-Z9129]
MRP8 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FCM; IHC-P; ELISA; WB
- Conjugation:
- Unconjugated
NeuroMab™ Mouse Anti-ITGAM Monoclonal Antibody (CBP7087) [CAT#: NAB-0720-Z9125]
CD11b Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; IHC-P; Protein Array
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3432
NeuroMab™ Mouse Anti-PTPRC Monoclonal Antibody (CBP7086) [CAT#: NAB-0720-Z9122]
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat
- Applications:
- FCM; ICC; IF; IHC-Fr
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3431
NeuroMab™ Rabbit Anti-ABCC11 Monoclonal Antibody (CBP7085) [CAT#: NAB-0720-Z9121]
MRP8 Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB; IP
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3430
NeuroMab™ Mouse Anti-PTPRC Monoclonal Antibody (CBP7084) [CAT#: NAB-0720-Z9119]
CD45 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IP; IHC-Fr; IHC-P; WB; FCM; ICC; IF
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3429
NeuroMab™ Mouse Anti-AIF1 Monoclonal Antibody (CBP7083) [CAT#: NAB-0720-Z9118]
Iba1 Mouse Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- Protein Array; IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3428
NeuroMab™ Rabbit Anti-ITGAM Monoclonal Antibody (CBP7082) [CAT#: NAB-0720-Z9116]
CD11b Rabbit Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB; IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3427
Product
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Cells
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Tracers
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Biospecimens
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