Creative Biolabs

Mouse Anti-Human α-Synuclein 103-108 Monoclonal Antibody (Clone 4B12) [HRP]

[CAT#: NAB2010649LS]

Anti α-Synuclein, 103-108 Monoclonal Antibody [HRP]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC-P; WB; ELISA

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Description
α-Synuclein is expressed principally in the nervous system, but it is also produced in other tissues, including the skin. In the brain, the protein is primarily neuronal, but it is also present in glia. Neuronal α-synuclein is concentrated in presynaptic nerve terminals, interacts with plasma membrane phospholipids, and is also present in nuclei and mitochondria. At least three isoforms of synuclein are produced through alternative splicing. The most common isoform is a 140 amino acid-long transcript. Other isoforms are a-synuclein-126, lacking residues 41-54; and α-synuclein-112, which lacks residues 103-130. α-Synuclein's physiological role is poorly understood, but the protein has been implicated in regulating dopamine release and transport, synaptic vesicle clustering, and functioning as a SNARE-complex chaperone. α-Synuclein fibrils are major component of the intracellular Lewy bodies that are associated with Parkinson's disease, Lewy body dementia, and multiple system atrophy.
Immunogen
This antibody was developed using a purified, E. coli produced human α-synuclein.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1, κ
Clone Number
4B12
Applications
IHC-P; WB; ELISA
Application Notes
IHC-P (1.0-5.0 µg/mL); WB (1.0-5.0 µg/mL); ELISA (0.5-2.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
HRP
Form
Liquid
Formulation
This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
Concentration
0.5 mg/ml
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Handling Advice
Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Alpha Synuclein
Official Name
SNCA
Full Name
Alpha-synuclein
Alternative Names
SNCA; NACP; PARK1; PARK4; PD1; synuclein alpha
Gene ID
6622 (Human); 20617 (Mouse)
Uniprot ID
P37840 (Human); P37840 (Mouse)
1. Lee JM, et al. 2017. J Neuropathol Exp Neurol. 76(1):2.
2. Kang SS, et al. 2017. Proc Natl Acad Sci. 114(5): 1183.
3. Valdes P, et al. 2016. Front Neuroanat. 10:123.
4. Emamzadeh FN. 2016. J Res Med Sci. 9(21):29.
Neural Antibodies
Neural Proteins & Peptides
Neural Cell Lines
Neural Genes
Kits
For Research Use Only. Not For Clinical Use.
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